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Lopid

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Lopid

Lopid

Lopid Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Lopid (gemfibrozil) Tablets is used to treat very high cholesterol and triglyceride levels in people with pancreatitis, and is also used to lower the risk of stroke, heart attack, or other heart complications in people with high cholesterol and triglycerides who have not been helped by other treatments. It is a lipid regulating agent. This medication is available in generic form. Common side effects include stomach upset, stomach/abdominal pain, or unusual taste.

The recommended dose of Lopid for adults is 1200 mg administered in two divided doses 30 minutes before the morning and evening meals. Lopid may interact with blood thinners, insulin or oral diabetes medication, or other cholesterol-lowering drugs. Tell your doctor all medications you use. Lopid is not recommended for use during pregnancy. It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended.

Our Lopid (gemfibrozil) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Lopid in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • sharp pain in your upper stomach (especially after eating);
  • jaundice (yellowing of your skin or eyes);
  • blurred vision, eye pain, or seeing halos around lights;
  • pain or burning when you urinate;
  • unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine; or
  • pale skin, easy bruising, unusual bleeding, feeling light-headed or short of breath, rapid heart rate, trouble concentrating, purple or red pinpoint spots under your skin.

Less serious side effects may include:

  • upset stomach;
  • mild stomach pain, nausea, vomiting, diarrhea;
  • headache, dizziness, drowsiness;
  • mild joint or muscle pain;
  • loss of interest in sex, impotence, difficulty having an orgasm;
  • numbness or tingly feeling; or
  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lopid (Gemfibrozil) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Lopid Overview - Patient Information: Side Effects

SIDE EFFECTS: Stomach upset, stomach/abdominal pain, or unusual taste may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may infrequently cause gallstones and liver problems. If you notice any of the following unlikely but serious side effects, tell your doctor immediately: severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine.

This drug may infrequently cause muscle problems (which can rarely lead to a very serious condition called rhabdomyolysis). Tell your doctor immediately if you develop any of these symptoms: muscle pain/tenderness/weakness (especially with fever or unusual tiredness), change in the amount of urine.

Tell your doctor immediately if any of these rare but serious side effects occur: signs of infection (such as fever, persistent sore throat), easy bruising/bleeding, unusual tiredness, irregular heartbeat, numbness/tingling of arms/legs.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Lopid (Gemfibrozil)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Lopid FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

In the double-blind controlled phase of the primary prevention component of the Helsinki Heart Study, 2046 patients received LOPID for up to five years. In that study, the following adverse reactions were statistically more frequent in subjects in the LOPID group:

  LOPID
(N = 2046)
PLACEBO
(N = 2035)
Frequency in
percent of subjects
Gastrointestinal reactions 34.2 23.8
Dyspepsia 19.6 11.9
Abdominal pain 9.8 5.6
Acute appendicitis (histologically confirmed in most cases where data were available) 1.2 0.6
Atrial fibrillation 0.7 0.1
Adverse events reported by more than 1% of subjects, but without a significant difference between groups:
Diarrhea 7.2 6.5
Fatigue 3.8 3.5
Nausea/Vomiting 2.5 2.1
Eczema 1.9 1.2
Rash 1.7 1.3
Vertigo 1.5 1.3
Constipation 1.4 1.3
Headache 1.2 1.1

Gallbladder surgery was performed in 0.9% of LOPID and 0.5% of placebo subjects in the primary prevention component, a 64% excess, which is not statistically different from the excess of gallbladder surgery observed in the clofibrate group compared to the placebo group of the WHO study. Gallbladder surgery was also performed more frequently in the LOPID group compared to the placebo group (1.9% versus 0.3%, p=0.07) in the secondary prevention component. A statistically significant increase in appendectomy in the gemfibrozil group was seen also in the secondary prevention component (6 on gemfibrozil versus 0 on placebo, p=0.014).

Nervous system and special senses adverse reactions were more common in the LOPID group. These included hypesthesia, paresthesias, and taste perversion. Other adverse reactions that were more common among LOPID treatment group subjects but where a causal relationship was not established include cataracts, peripheral vascular disease, and intracerebral hemorrhage.

From other studies it seems probable that LOPID is causally related to the occurrence of MUSCULOSKELETAL SYMPTOMS (see WARNINGS), and to ABNORMAL LIVER FUNCTION TESTS and HEMATOLOGIC CHANGES (see PRECAUTIONS).

Reports of viral and bacterial infections (common cold, cough, urinary tract infections) were more common in gemfibrozil treated patients in other controlled clinical trials of 805 patients. Additional adverse reactions that have been reported for gemfibrozil are listed below by system. These are categorized according to whether a causal relationship to treatment with LOPID is probable or not established:

  CAUSAL RELATIONSHIP PROBABLE CAUSAL RELATIONSHIP NOT ESTABLISHED
General:   weight loss
Cardiac:   extrasystoles
Gastrointestinal: cholestatic jaundice pancreatitis
hepatoma
colitis
Central Nervous System: dizziness
somnolence
paresthesia
peripheral neuritis
decreased libido
depression
headache
confusion
convulsions
syncope
Eye: blurred vision retinal edema
Genitourinary: impotence decreased male fertility
renal dysfunction
Musculoskeletal: myopathy
myasthenia
myalgia
painful extremities
arthralgia
synovitis
rhabdomyolysis (see WARNINGS and DRUG INTERACTIONSunder PRECAUTIONS)
 
Clinical Laboratory: increased creatine
phosphokinase
increased bilirubin
increased liver transaminases (AST, ALT)
increased alkaline phosphatase
positive antinuclear antibody
Hematopoietic: anemia
leukopenia
bone marrow hypoplasia
eosinophilia
thrombocytopenia
Immunologic: angioedema laryngeal edema urticaria anaphylaxis
Lupus-like syndrome
vasculitis
Integumentary: exfoliative
dermatitis rash
dermatitis
pruritus
alopecia
photosensitivity

Additional adverse reactions that have been reported include cholecystitis and cholelithiasis (see WARNINGS).

Read the entire FDA prescribing information for Lopid (Gemfibrozil) »

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Lopid - User Reviews

Lopid User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Lopid sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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