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Lopressor Side Effects Center
Medical Editor: Charles Patrick Davis, MD, PhD
Lopressor (metoprolol tartrate) Tablets, USP and (metoprolol tartrate) Injection, USP is a selective beta-adrenoreceptor blocking agent used to treat hypertension, angina, and heart attacks. Lopressor is available as a generic termed metoprolol. Common side effects of Lopressor may include GI (nausea, vomiting, dry mouth, gas, heartburn, or constipation), dizziness, and tired, depression, and rash.
Lopressor USP is available as 50 and 100 mg strength tablets for oral administration and as (metoprolol tartrate) Injection, USP in 5 mg strength, in 5 ml ampoules for IV administration. Usual oral dosage is 100 mg per day in single or divided doses; IV begins with a 5 mg injection. Serious side effects of Lopressor include wheezing, shortness of breath, swelling, or irregular, rapid heartbeats. Patients with bronchospastic disease should not take Lopressor. Lopressor should be stopped several days before clonidine is stopped to avoid rebound hypertension. There are no adequate and well-controlled studies of Lopressor in pregnant women, and caution should be exercised when Lopressor is administered to a woman breastfeeding an infant as small amounts of Lopressor are excreted in breast milk. Safety and effectiveness of Lopressor in pediatric patients have not been established.
Our Lopressor Tablets, USP and Injection, USP Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Lopressor in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- chest pain, pounding heartbeats or fluttering in your chest;
- feeling light-headed, fainting;
- feeling short of breath, even with mild exertion;
- swelling of your hands or feet;
- nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- wheezing, trouble breathing;
- depression, confusion, memory problems, hallucinations; or
- cold feeling in your hands and feet.
Less serious side effects may include:
- dry mouth, constipation, heartburn, vomiting, diarrhea;
- decreased sex drive, impotence, or difficulty having an orgasm;
- headache, drowsiness, tired feeling;
- sleep problems (insomnia); or
- anxiety, nervousness.
Read the entire detailed patient monograph for Lopressor (Metoprolol Tartrate) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Lopressor Overview - Patient Information: Side Effects
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
This drug may reduce blood flow to your hands and feet, causing them to feel cold. Smoking may worsen this effect. Dress warmly and avoid tobacco use.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: very slow heartbeat, severe dizziness, fainting, blue fingers/toes, trouble breathing, new or worsening symptoms of heart failure (such as swelling ankles/feet, severe tiredness, shortness of breath, unexplained/sudden weight gain), mental/mood changes (such as confusion, mood swings, depression).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Lopressor (Metoprolol Tartrate)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Lopressor FDA Prescribing Information: Side Effects
Hypertension and Angina
Most adverse effects have been mild and transient.
Central Nervous System: Tiredness and dizziness have occurred in about 10 of 100 patients. Depression has been reported in about 5 of 100 patients. Mental confusion and short-term memory loss have been reported. Headache, nightmares, and insomnia have also been reported.
Cardiovascular: Shortness of breath and bradycardia have occurred in approximately 3 of 100 patients. Cold extremities; arterial insufficiency, usually of the Raynaud type; palpitations; congestive heart failure; peripheral edema; and hypotension have been reported in about 1 of 100 patients. Gangrene in patients with pre-existing severe peripheral circulatory disorders has also been reported very rarely. (See CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS.)
Gastrointestinal: Diarrhea has occurred in about 5 of 100 patients. Nausea, dry mouth, gastric pain, constipation, flatulence, and heartburn have been reported in about 1 of 100 patients. Vomiting was a common occurrence. Postmarketing experience reveals very rare reports of hepatitis, jaundice and non-specific hepatic dysfunction. Isolated cases of transaminase, alkaline phosphatase, and lactic dehydrogenase elevations have also been reported.
There have been rare reports of reversible alopecia, agranulocytosis, and dry eyes. Discontinuation of the drug should be considered if any such reaction is not otherwise explicable. There have been very rare reports of weight gain, arthritis, and retroperitoneal fibrosis (relationship to Lopressor (metoprolol tartrate) has not been definitely established).
The oculomucocutaneous syndrome associated with the beta blocker practolol has not been reported with Lopressor (metoprolol tartrate) .
Central Nervous System: Tiredness has been reported in about 1 of 100 patients. Vertigo, sleep disturbances, hallucinations, headache, dizziness, visual disturbances, confusion, and reduced libido have also been reported, but a drug relationship is not clear.
Cardiovascular: In the randomized comparison of Lopressor and placebo described in the CLINICAL PHARMACOLOGY section, the following adverse reactions were reported:
|Hypotension (systolic BP <90 mmHg)||27.4%||23.2%|
|Bradycardia (heart rate <40 beats/min)||15.9%||6.7%|
|Second- or third-degree heart block||4.7%||4.7%|
|First-degree heart block (P-R >0.26 sec)||5.3%||1.9%|
Respiratory: Dyspnea of pulmonary origin has been reported in fewer than 1 of 100 patients.
Gastrointestinal: Nausea and abdominal pain have been reported in fewer than 1 of 100 patients.
Dermatologic: Rash and worsened psoriasis have been reported, but a drug relationship is not clear.
Potential Adverse Reactions
A variety of adverse reactions not listed above have been reported with other beta-adrenergic blocking agents and should be considered potential adverse reactions to Lopressor (metoprolol tartrate) .
Central Nervous System: Reversible mental depression progressing to catatonia; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance on neuropsychometrics.
Cardiovascular: Intensification of AV block (see CONTRAINDICATIONS).
Hematologic: Agranulocytosis, nonthrombocytopenic purpura, thrombocytopenic purpura.
The following adverse reactions have been reported during postapproval use of Lopressor (metoprolol tartrate) : confusional state, an increase in blood triglycerides and a decrease in High Density Lipoprotein (HDL). Because these reports are from a population of uncertain size and are subject to confounding factors, it is not possible to reliably estimate their frequency.
Read the entire FDA prescribing information for Lopressor (Metoprolol Tartrate) »
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