Brand Names: Lotrel

Generic Name: amlodipine and benazepril (Pronunciation: am LOE di peen and ben AY ze pril)

• What is amlodipine and benazepril (Lotrel)?
• What are the possible side effects of amlodipine and benazepril (Lotrel)?
• What is the most important information I should know about amlodipine and benazepril (Lotrel)?
• What should I discuss with my healthcare provider before taking amlodipine and benazepril (Lotrel)?
• How should I take amlodipine and benazepril (Lotrel)?
• What happens if I miss a dose (Lotrel)?
• What happens if I overdose (Lotrel)?
• What should I avoid while taking amlodipine and benazepril (Lotrel)?
• What other drugs will affect amlodipine and benazepril (Lotrel)?
• Where can I get more information?

What is amlodipine and benazepril (Lotrel)?

Amlodipine is in a group of drugs called calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Benazepril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Benazepril also widens blood vessels and also prevents the body from retaining water.

Amlodipine and benazepril is used to treat high blood pressure (hypertension). It is usually given after other blood pressure medications have been tried without successful treatment.

Amlodipine and benazepril may also be used for purposes not listed in this medication guide.

Amlodipine-Benazepril 10 mg-20 mg-TEV

purple, imprinted with 93 7373

Amlodipine-Benazepril 10 mg-40 mg-TEV

blue, imprinted with TEVA, 7671

Amlodipine-Benazepril 2.5 mg-10 mg-TEV

white, imprinted with 93 7370

Amlodipine-Benazepril 5 mg-10 mg-TEV

tan/white, imprinted with 93 7371

Amlodipine-Benazepril 5 mg-20 mg-TEV

pink/white, imprinted with 93 7372

Amlodipine-Benazepril 5 mg-40 mg-TEV

blue, imprinted with TEVA, 7670

Lotrel 10 mg-20 mg

purple, imprinted with LOTREL 0364

Lotrel 10-40 mg

blue, imprinted with Lotrel 0379

Lotrel 2.5 mg-10 mg

white, imprinted with LOTREL 2255

Lotrel 2.5-10mg

white, imprinted with LOTREL 2255

Lotrel 5 mg-10 mg

orange, imprinted with LOTREL 2260

Lotrel 5-10mg

brown, imprinted with LOTREL 2260

Lotrel 5-20

pink, imprinted with LOTREL 2265

Lotrel 5-40 mg

blue, imprinted with Lotrel, 0384

What are the possible side effects of amlodipine and benazepril (Lotrel)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.

Some side effects of amlodipine and benazepril may not occur until after you have been using the medication for several months.

Call your doctor at once if you have any of these serious side effects:

• trouble swallowing;
• chest pain;
• feeling like you might pass out;
• urinating more or less than usual, or not at all;
• swelling, rapid weight gain;
• fever, chills, sore throat, body aches, flu symptoms; or
• nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• cough;
• dizziness, headache;
• sleep problems (insomnia);
• flushing (warmth, redness, or tingling under your skin);
• diarrhea, constipation;
• muscle pain; or
• loss of interest in sex.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the Lotrel (amlodipine besylate and benazepril hcl) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about amlodipine and benazepril (Lotrel)?

You should not use this medication if you are allergic to amlodipine (Norvasc) or benazepril (Lotensin), or if you have ever had angioedema (hives or severe swelling of deep skin tissues sometimes caused by allergic reaction).

You should not use amlodipine and benazepril if you are allergic to any other ACE inhibitor, such as captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

Amlodipine and benazepril may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Some side effects of amlodipine and benazepril may not occur until after you have been using the medication for several months.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.