Lotrisone (Clotrimazole and Betamethasone) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 8, 2012

Lotrisone

Ringworm »

What does the term ringworm mean?

The term ringworm or ringworms refers to fungal infections that are on the surface of the skin. The name is derived from the early belief that the infection was due to a worm, which it is not. Ringworm is a fungal infection in the skin. Nevertheless, the name ringworm remains. Some of these fungi produce round spots on the skin, but many do not. On the other hand, many round, red spots on the skin are not due to a fungal infection. A physical examination of the affected skin, evaluation of skin scrapings under the microscope, and culture tests can help doctors make the appropriate distinctions. A proper diagnosis is essential to successful treatment.

The medical term for ringworm is tinea. (Tinea is the Latin name for a growing worm.) Doctors add another word to indicate where the fungus is located. Tinea capitis, for instance, refers to scalp ringworm, tinea corporis to fungus of the body, tine...

Read the Ringworm article »

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LOTRISONE®
(clotrimazole and betamethasone dipropionate) Cream

LOTRISONE®
(clotrimazole and betamethasone dipropionate) Lotion

FOR TOPICAL USE ONLY. NOT FOR OPHTHALMIC, ORAL, OR INTRAVAGINAL USE. NOT RECOMMENDED FOR PATIENTS UNDER THE AGE OF 17 YEARS AND NOT RECOMMENDED FOR DIAPER DERMATITIS.

DRUG DESCRIPTION

LOTRISONE® (clotrimazole and betamethasone) Cream and Lotion contain combinations of clotrimazole, a synthetic antifungal agent, and betamethasone dipropionate, a synthetic corticosteroid, for dermatologic use.

Chemically, clotrimazole is 1–(o-chloro-α,α-diphenylbenzyl) imidazole, with the empirical formula C₂₂H₁₇CIN₂, a molecular weight of 344.84, and the following structural formula:

Clotrimazole Structural Formula Illustration

Clotrimazole is an odorless, white crystalline powder, insoluble in water and soluble in ethanol.

Betamethasone dipropionate has the chemical name 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate, with the empirical formula C₂₈H₃₇FO₇, a molecular weight of 504.59, and the following structural formula:

Betamethasone dipropionate Structural Formula Illustration

Betamethasone dipropionate is a white to creamy white, odorless crystalline powder, insoluble in water.

Each gram of LOTRISONE (clotrimazole and betamethasone) Cream contains 10 mg clotrimazole and 0.643 mg betamethasone dipropionate (equivalent to 0.5 mg betamethasone), in a hydrophilic cream consisting of purified water, mineral oil, white petrolatum, cetyl alcohol plus stearyl alcohol, ceteareth-30, propylene glycol, sodium phosphate monobasic monohydrate, and phosphoric acid; benzyl alcohol as preservative.

LOTRISONE (clotrimazole and betamethasone) Cream may contain sodium hydroxide. LOTRISONE (clotrimazole and betamethasone) Cream is smooth, uniform, and white to off-white in color.

Each gram of LOTRISONE (clotrimazole and betamethasone) Lotion contains 10 mg clotrimazole and 0.643 mg betamethasone dipropionate (equivalent to 0.5 mg betamethasone), in a hydrophilic base of purified water, mineral oil, white petrolatum, cetyl alcohol plus stearyl alcohol, ceteareth-30, propylene glycol, sodium phosphate monobasic monohydrate, and phosphoric acid; benzyl alcohol as a preservative.

LOTRISONE (clotrimazole and betamethasone) Lotion may contain sodium hydroxide. LOTRISONE (clotrimazole and betamethasone) Lotion is opaque and white in color.

What are the possible side effects of betamethasone and clotrimazole topical (Lotrisone)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these signs that you may be absorbing betamethasone topical through your skin or gums:

swelling, redness, or any signs of new infection;
severe burning or stinging of treated skin;
weight gain, rounding of the face;
increased thirst...

Read All Potential Side Effects and See Pictures of Lotrisone »

What are the precautions when taking clotrimazole and betamethasone (Lotrisone)?

Before using this medication, tell your doctor or pharmacist if you are allergic to clotrimazole or betamethasone; or to other azole antifungals (e.g., ketoconazole) or corticosteroids (e.g., triamcinolone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: immune system problems, poor blood circulation.

Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially thinning skin.

Rarely, using corticosteroid medications for a long time or over large areas of skin can make it...

Read All Potential Precautions of Lotrisone »

Last reviewed on RxList: 6/10/2009
This monograph has been modified to include the generic and brand name in many instances.