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Lotrisone

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Since 2009, the Food and Drug Administratio"...

Lotrisone

LOTRISONE®
(clotrimazole and betamethasone dipropionate) Cream

DRUG DESCRIPTION

LOTRISONE (clotrimazole and betamethasone dipropionate) cream, 1%/0.05%, contains combinations of clotrimazole, an azole antifungal, and betamethasone dipropionate, a corticosteroid, for topical use.

Chemically, clotrimazole is 1–(o-chloro-α,α-diphenylbenzyl) imidazole, with the empirical formula C22H17CLN2, a molecular weight of 344.84, and the following structural formula:

Clotrimazole - Structural Formula Illustration

Clotrimazole is an odorless, white crystalline powder, insoluble in water and soluble in ethanol. Betamethasone dipropionate has 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21- dipropionate, with the empirical formula C28H37FO7, a molecular weight of 504.59, and the following structural formula:

Betamethasone dipropionate -  Structural Formula Illustration

Betamethasone dipropionate is a white to creamy-white, odorless crystalline powder, insoluble in water.

Each gram of LOTRISONE cream contains 10 mg clotrimazole and 0.643 mg betamethasone dipropionate (equivalent to 0.5 mg betamethasone), in a white to off-white, hydrophilic cream consisting of benzyl alcohol as a preservative, ceteareth-30, cetyl alcohol plus stearyl alcohol, mineral oil, phosphoric acid, propylene glycol, purified water, sodium phosphate monobasic monohydrate, and white petrolatum.

What are the possible side effects of betamethasone and clotrimazole topical ()?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these signs that you may be absorbing betamethasone topical through your skin or gums:

  • swelling, redness, or any signs of new infection;
  • severe burning or stinging of treated skin;
  • weight gain, rounding of the face;
  • increased thirst or hunger, urinating more than usual; or
  • anxiety,...

Read All Potential Side Effects and See Pictures of Lotrisone »

What are the precautions when taking clotrimazole and betamethasone (Lotrisone)?

Before using this medication, tell your doctor or pharmacist if you are allergic to clotrimazole or betamethasone; or to other azole antifungals (e.g., ketoconazole) or corticosteroids (e.g., triamcinolone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: immune system problems, poor blood circulation.

Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially thinning skin.

Rarely, using corticosteroid medications for a long time or over large areas of skin can make it...

Read All Potential Precautions of Lotrisone »

Last reviewed on RxList: 5/1/2014
This monograph has been modified to include the generic and brand name in many instances.

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Lotrisone - User Reviews

Lotrisone User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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