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Lotrisone Side Effects Center
Pharmacy Editor: Melissa Conrad Stöppler, MD
Lotrisone (clotrimazole and betamethasone) is a cream or lotion used to treat or prevent fungal infections of the skin. Clotrimazole is an antifungal antibiotic, and betamethasone is a topical steroid that reduces itching, swelling, and redness of the skin. The combination of betamethasone and clotrimazole topical is used to treat fungal skin infections such as athlete's foot, jock itch, and ringworm.
Side effects can include mild itching, skin irritation, changes in skin color, increased acne, or scarring or thickening of the skin. Lotrisone is not recommended for people under 17 years of age. There are no adequate studies in pregnant women of the teratogenic effects of topically applied corticosteroids, so this drug should be used during pregnancy only if the potential benefit justifies the potential risk. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk.
Our Lotrisone Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Lotrisone in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these signs that you may be absorbing betamethasone topical through your skin or gums:
- swelling, redness, or any signs of new infection;
- severe burning or stinging of treated skin;
- weight gain, rounding of the face;
- increased thirst or hunger, urinating more than usual; or
- anxiety, depressed mood.
Less serious side effects may include:
- mild skin itching or irritation;
- dry skin;
- changes in skin color;
- increased acne; or
- scarring or thinning of the skin.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Lotrisone (Clotrimazole and Betamethasone) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Lotrisone Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: extreme hair growth, skin thinning/discoloration, acne, stretch marks, "hair bumps" (folliculitis).
Rarely, it is possible this medication will be absorbed from the skin into the bloodstream. This can lead to side effects of too much corticosteroid. These side effects are more likely in children, and in people who use this medication for a long time or over large areas of the skin. Tell your doctor right away if any of the following side effects occur: unusual/extreme tiredness, weight loss, headache, swelling ankles/feet, increased thirst/urination, vision problems.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Lotrisone (Clotrimazole and Betamethasone)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Lotrisone FDA Prescribing Information: Side Effects
Adverse reactions reported for LOTRISONE® (clotrimazole and betamethasone) Cream in clinical trials were paresthesia in 1.9% of patients, and rash, edema, and secondary infection, each in less than 1% of patients.
Adverse reactions reported for LOTRISONE® (clotrimazole and betamethasone) Lotion in clinical trials were burning and dry skin in 1.6% of patients and stinging in less than 1% of patients.
The following local adverse reactions have been reported with topical corticosteroids and may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria, capillary fragility (ecchymoses), telangiectasia, and sensitization (local reactions upon repeated application of product). In the pediatric population, reported adverse events for LOTRISONE (clotrimazole and betamethasone) Cream include growth retardation, benign intracranial hypertension, Cushing's syndrome (HPA axis suppression), and local cutaneous reactions, including skin atrophy.
Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.
Read the entire FDA prescribing information for Lotrisone (Clotrimazole and Betamethasone) »
Additional Lotrisone Information
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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