Signs and symptoms of overdosage will depend on the amount ingested and individual patient tolerance. As would be expected from the pharmacologic actions of the drug, the clinical findings may range from mild depression of the CNS and cardiovascular systems to profound hypotension, respiratory depression, and unconsciousness. The possibility of occurrence of extrapyramidal symptoms and/or convulsive seizures should be kept in mind. Renal failure following loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) overdosage has also been reported.
The treatment of overdosage is essentially symptomatic and supportive. Early gastric lavage and extended dialysis might be expected to be beneficial. Centrally-acting emetics may have little effect because of the antiemetic action of loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) . In addition, emesis should be avoided because of the possibility of aspiration of vomitus. Avoid analeptics, such as pentylenetetrazol, which may cause convulsions. Severe hypotension might be expected to respond to the administration of norepinephrine or phenylephrine. EPINEPHRINE SHOULD NOT BE USED SINCE ITS USE IN A PATIENT WITH PARTIAL ADRENERGIC BLOCKADE MAY FURTHER LOWER THE BLOOD PRESSURE. Severe extrapyramidal reactions should be treated with anticholinergic antiparkinson agents or diphenhydramine hydrochloride, and anticonvulsant therapy should be initiated as indicated. Additional measures include oxygen and intravenous fluids.
Loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) is contraindicated in comatose or severe drug-induced depressed states (alcohol, barbiturates, narcotics, etc.).
Loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) is contraindicated in individuals with known hypersensitivity to dibenzoxazepines.
Last reviewed on RxList: 8/19/2008
This monograph has been modified to include the generic and brand name in many instances.
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