Loxapine

Loxapine Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Loxapine (loxapine succinate) Capsule is an antipsychotic medication used to treat schizophrenia. It is available in generic form. Common side effects of Loxapine include dizziness, drowsiness, blurred vision, puffiness in your face, feeling restless or agitated, sleep problems, breast swelling or discharge, changes in menstrual cycle, nausea, vomiting, constipation, changes in weight, dry mouth, stuffy nose, and skin rash.

The recommended dosage of Loxapine is 10 mg twice a day. Atreza, Pamine, bronchodilators, Robinul, Cantil, bladder and urinary medications, and irritable bowel medications may interact with Loxapine. Tell your doctor all medications you take. Do not drive, use machinery, or do any activity that requires alertness when taking Loxapine. Avoid drinking alcohol while taking Loxapine. Do not take Loxapine if you are pregnant or breastfeeding.

Our Loxapine (loxapine succinate) Capsule Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Loxapine in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using loxapine and call your doctor at once if you have a serious side effect such as:

  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • tremor (uncontrolled shaking);
  • trouble swallowing;
  • seizure (convulsions);
  • easy bruising or bleeding, unusual weakness;
  • fever, chills, body aches, flu symptoms;
  • vision changes;
  • severe constipation; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • dizziness or drowsiness;
  • blurred vision;
  • puffiness in your face;
  • feeling restless or agitated;
  • sleep problems (insomnia);
  • breast swelling or discharge;
  • changes in your menstrual periods;
  • nausea, vomiting, constipation;
  • changes in weight;
  • dry mouth, stuffy nose; or
  • mild skin rash, itching, or flaking.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Loxapine (Loxapine Succinate) »

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Loxapine FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

CNS Effects: Manifestations of adverse effects on the central nervous system, other than extrapyramidal effects, have been seen infrequently. Drowsiness, usually mild, may occur at the beginning of therapy or when dosage is increased. It usually subsides with continued loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) therapy. The incidence of sedation has been less than that of certain aliphatic phenothiazines and slightly more than the piperazine phenothiazines. Dizziness, faintness, staggering gait, shuffling gait, muscle twitching, weakness, insomnia, agitation, tension, seizures, akinesia, slurred speech, numbness, and confusional states have been reported. Neuroleptic malignant syndrome (NMS) has been reported (see WARNINGS).

Extrapyramidal Symptoms - Neuromuscular (extrapyramidal) reactions during the administration of loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) have been reported frequently, often during the first few days of treatment. In most patients, these reactions involved parkinsonian-like symptoms such as tremor, rigidity, excessive salivation, and masked facies. Akathisia (motor restlessness) also has been reported relatively frequently. These symptoms are usually not severe and can be controlled by reduction of loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) dosage or by administration of antiparkinson drugs in usual dosage.

DystoniaClass effect: Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups.

Persistent Tardive Dyskinesia- As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been discontinued. The risk appears to be greater in elderly patients on high-dose therapy, especially females. The symptoms are persistent and in some patients appear to be irreversible. The syndrome is characterized by rhythmical involuntary movement of the tongue, face, mouth or jaw (e.g., protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements). Sometimes these may be accompanied by involuntary movements of extremities.

There is no known effective treatment for tardive dyskinesia; antiparkinson agents usually do not alleviate the symptoms of this syndrome. It is suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment, or increase the dosage of the agent, or switch to a different antipsychotic agent, the syndrome may be masked. It has been suggested that fine vermicular movements of the tongue may be an early sign of the syndrome, and if the medication is stopped at that time the syndrome may not develop.

Cardiovascular Effects: Tachycardia, hypotension, hypertension, orthostatic hypotension, lightheadedness, and syncope have been reported.

A few cases of ECG changes similar to those seen with phenothiazines have been reported. It is not known whether these were related to loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) administration.

Hematologic: Rarely, agranulocytosis, thrombocytopenia, leukopenia.

Skin: Dermatitis, edema (puffiness of face), pruritus, rash, alopecia, and seborrhea have been reported with loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) .

Anticholinergic Effects: Dry mouth, nasal congestion, constipation, blurred vision, urinary retention, and paralytic ileus have occurred.

Gastrointestinal: Nausea and vomiting have been reported in some patients. Hepatocellular injury (i.e., SGOT/SGPT elevation) has been reported in association with loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) administration and rarely, jaundice and/or hepatitis questionably related to loxapine (loxapine (loxapine (loxapine succinate) succinate) succinate) treatment.

Other Adverse Reactions: Weight gain, weight loss, dyspnea, ptosis, hyperpyrexia, flushed facies, headache, paresthesia, and polydipsia have been reported in some patients. Rarely, galactorrhea, amenorrhea, gynecomastia, and menstrual irregularity of uncertain etiology have been reported.

Read the entire FDA prescribing information for Loxapine (Loxapine Succinate) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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