Loxitane (Loxapine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 8, 2012

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Loxitane

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Loxitane
(loxapine) Capsules, Oral Concentrate, Intramuscular

DRUG DESCRIPTION

LOXITANE loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Chemically, it is 2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz[ b,f ] [1,4]oxazepine. It is present in capsules as the succinate salt, and in the concentrate and parenteral primarily as the hydrochloride salt.

CAPSULES Each capsule contains loxapine succinate equivalent to 5, 10, 25, or 50 mg of loxapine base and the following inactive ingredients: Blue 1, Gelatin, Lactose, Magnesium Stearate, Titanium Dioxide, and Yellow 10. Additionally, the 5 mg capsule contains Red 33, the 10 mg capsule contains Red 28 and Red 33, and the 25 mg capsule contains FD&C Yellow No. 6.

ORAL CONCENTRATE Each mL contains loxapine hydrochloride equivalent to 25 mg of loxapine base and propylene glycol as an inactive ingredient.

Hydrochloric acid and, if necessary, sodium hydroxide are used to adjust pH to approximately 5.8 during manufacture.

INTRAMUSCULAR (Sterile) - Not for Intravenous Use - Each mL contains loxapine hydrochloride equivalent to 50 mg of loxapine base. Inactive Ingredients: Polysorbate 80 NF 5% w/v, Propylene Glycol 70% v/v, and Water for Injection qs ad 100% v.

Hydrochloric acid and, if necessary, sodium hydroxide are used to adjust pH to approximately 5.5 during manufacture.

What are the possible side effects of loxapine (Loxitane, Loxitane C)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking loxapine and call your doctor at once if you have a serious side effect such as:

very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
restless muscle movements in your eyes, tongue, jaw, or neck;
tremor (uncontrolled shaking);
trouble...

Read All Potential Side Effects and See Pictures of Loxitane »

What are the precautions when taking loxapine (Loxitane)?

See also Warning section.

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood problems (such as low red/white/platelet blood cell counts), a certain eye condition (glaucoma), heart problems (such as fast/irregular heartbeat, low blood pressure), liver disease, a brain disorder/tumor/injury, drug/alcohol/substance abuse, breast cancer, Parkinson's disease, seizures, a certain severe reaction to other antipsychotic-type medications (neuroleptic malignant...

Read All Potential Precautions of Loxitane »

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.