Lupron Depot 11.25 mg (Leuprolide Acetate for Depot Suspension) Drug Information: Overdosage and Contraindications

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May 27, 2012

Lupron Depot 11.25

Endometriosis »

What is endometriosis?

Endometriosis is the abnormal growth of cells (endometrial cells) similar to those that form the inside of the uterus, but in a location outside of the uterus. Endometrial cells are cells that are shed each month during menstruation. The cells of endometriosis attach themselves to tissue outside the uterus and are called endometriosis implants. These implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines, and on the surface lining of the pelvic cavity. They can also be found in the vagina, cervix, and bladder, although less commonly than other locations in the pelvis. Rarely, endometriosis implants can occur outside the pelvis, on the liver, in old surgery scars, and even in or around the lung or brain. Endometrial implants, while they can cause problems, are benign (not cancerous).

Who is affected by endometriosis?

Endometriosis affects w...

Read the Endometriosis article »

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Lupron Depot 11.25 mg

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OVERDOSE

In clinical trials using daily subcutaneous leuprolide acetate in patients with prostate cancer, doses as high as 20 mg/day for up to two years caused no adverse effects differing from those observed with the 1 mg/day dose.

CONTRAINDICATIONS

Hypersensitivity to GnRH, GnRH agonist analogs or any of the excipients in LUPRON DEPOT.
Undiagnosed abnormal vaginal bleeding.
LUPRON DEPOT is contraindicated in women who are or may become pregnant while receiving the drug. LUPRON DEPOT may cause fetal harm when administered to a pregnant woman. Major fetal abnormalities were observed in rabbits but not in rats after administration of LUPRON DEPOT throughout gestation. There was increased fetal mortality and decreased fetal weights in rats and rabbits. (See Pregnancy section.) The effects on fetal mortality are expected consequences of the alterations in hormonal levels brought about by the drug. If this drug is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.
Use in women who are breast-feeding. (See Nursing Mothers section.)
Norethindrone acetate is contraindicated in women with the following conditions:

Thrombophlebitis, thromboembolic disorders, cerebral apoplexy, or a past history of these conditions
Markedly impaired liver function or liver disease
Known or suspected carcinoma of the breast

Last reviewed on RxList: 4/12/2012
This monograph has been modified to include the generic and brand name in many instances.