Lupron Depot 22.5
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Lupron Depot 22.5
(leuprolide acetate for depot suspension) Injection, Powder, Lyophilized, For Suspension
Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH or LH-RH). The analog possesses greater potency than the natural hormone. The chemical name is 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L arginyl-N-ethyl-L-prolinamide acetate (salt) with the following structural formula:
LUPRON DEPOT (leuprolide acetate for depot suspension injection) –3 Month 22.5 mg is available in a prefilled dual-chamber syringe containing sterile lyophilized microspheres which, when mixed with diluent, become a suspension intended as an intramuscular injection to be given ONCE EVERY THREE MONTHS (84 days).
The front chamber of LUPRON DEPOT (leuprolide acetate for depot suspension injection) –3 Month 22.5 mg prefilled dual-chamber syringe contains leuprolide acetate (22.5 mg), polylactic acid (198.6 mg) and D-mannitol (38.9 mg). The second chamber of diluent contains carboxymethylcellulose sodium (7.5 mg), D-mannitol (75.0 mg), polysorbate 80 (1.5 mg), water for injection, USP, and glacial acetic acid, USP to control pH.
During the manufacture of LUPRON DEPOT (leuprolide acetate for depot suspension injection) –3 Month 22.5 mg, acetic acid is lost, leaving the peptide.
What are the possible side effects of leuprolide (Eligard, Lupron, Lupron Depot, Lupron Depot-Ped)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- bone pain, loss of movement in any part of your body;
- swelling, rapid weight gain;
- pain, burning, stinging, bruising, or redness where the medication was injected;
- feeling like you might pass out;
- sudden chest pain or discomfort, wheezing, dry cough or hack;
Last reviewed on RxList: 6/2/2010
This monograph has been modified to include the generic and brand name in many instances.
Additional Lupron Depot 22.5 Information
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