Lupron Depot 3.75
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Lupron Depot 3.75 mg
LUPRON DEPOT® 3.75 mg
(leuprolide acetate) for Depot Suspension
Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH
or LH-RH). The analog possesses greater potency than the natural hormone . The chemical name is
acetate (salt) with the following structural formula:
LUPRON DEPOT is available in a prefilled dual-chamber syringe containing sterile lyophilized microspheres which, when mixed with diluent, become a suspension intended as a monthly intramuscular injection.
The front chamber of LUPRON DEPOT 3.75 mg prefilled dual-chamber syringe contains leuprolide acetate (3.75 mg), purified gelatin (0.65 mg), DL-lactic and glycolic acids copolymer (33.1 mg), and D-mannitol (6.6 mg). The second chamber of diluent contains carboxymethylcellulose sodium (5 mg), D-mannitol (50 mg), polysorbate 80 (1 mg), water for injection, USP, and glacial acetic acid, USP to control pH.
During the manufacture of LUPRON DEPOT 3.75 mg, acetic acid is lost, leaving the peptide.
What are the possible side effects of leuprolide (Eligard, Lupron, Lupron Depot, Lupron Depot-Ped)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- bone pain, loss of movement in any part of your body;
- swelling, rapid weight gain;
- pain, burning, stinging, bruising, or redness where the medication was injected;
- feeling like you might pass out;
- sudden chest pain or discomfort, wheezing, dry cough or hack;
What are the precautions when taking leuprolide acetate injection (Lupron Depot 3.75 mg)?
Before using leuprolide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: vaginal bleeding of unknown cause.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood fat levels (e.g., high cholesterol, high triglycerides), depression.
In adults, leuprolide may weaken your bones and increase your risk for bone loss (osteoporosis) if used for a long time because it reduces estrogen...
Last reviewed on RxList: 2/2/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Lupron Depot 3.75 mg Information
- Lupron Depot 3.75 mg Drug Interactions Center: leuprolide (3 month) im
- Lupron Depot 3.75 mg Side Effects Center
- Lupron Depot 3.75 mg in detail including Side Effects and Drug Images
- Lupron Depot 3.75 mg Overview including Precautions
- Lupron Depot 3.75 mg FDA Approved Prescribing Information including Dosage
Lupron Depot 3.75 mg - User Reviews
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