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Lupron Depot 3.75

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Lupron Depot 3.75 mg

Overdosage
Contraindications

OVERDOSE

In rats subcutaneous administration of 250 to 500 times the recommended human dose, expressed on a per body weight basis, resulted in dyspnea, decreased activity, and local irritation at the injection site. There is no evidence that there is a clinical counterpart of this phenomenon. In early clinical trials using daily subcutaneous leuprolide acetate in patients with prostate cancer, doses as high as 20 mg/day for up to two years caused no adverse effects differing from those observed with the 1 mg/day dose.

CONTRAINDICATIONS

  1. Hypersensitivity to GnRH, GnRH agonist analogs or any of the excipients in LUPRON DEPOT.
  2. Undiagnosed abnormal vaginal bleeding.
  3. LUPRON DEPOT is contraindicated in women who are or may become pregnant while receiving the drug. LUPRON DEPOT may cause fetal harm when administered to a pregnant woman. Major fetal abnormalities were observed in rabbits but not in rats after administration of LUPRON DEPOT throughout gestation. There was increased fetal mortality and decreased fetal weights in rats and rabbits. (See Pregnancy section.) The effects on fetal mortality are expected consequences of the alterations in hormonal levels brought about by the drug. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.
  4. Use in women who are breast-feeding. (See Nursing Mothers section.)
  5. Norethindrone acetate is contraindicated in women with the following conditions:

Last reviewed on RxList: 2/2/2012
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
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Lupron Depot 3.75 mg - User Reviews

Lupron Depot 3.75 mg User Reviews

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