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LUSEDRA (fospropofol disodium injection) is an injection solution intended for intravenous administration as a sedative-hypnotic agent. LUSEDRA (fospropofol disodium injection) is an aqueous, sterile, nonpyrogenic, clear, colorless, iso-osmotic solution containing 35 mg/mL of fospropofol disodium. Fospropofol disodium is a water-soluble prodrug of propofol, chemically described as 2,6-diisopropylphenoxymethyl phosphate, disodium salt. The structural and molecular formulas are shown in Figure 1.

Molecular Formula: C₁₃H₁₉O₅PNa₂
Molecular Weight: 332.24
Figure 1. Structural and Molecular Formulas of Fospropofol Disodium

The inactive components include monothioglycerol (0.25 wt%) and tromethamine (0.12 wt%). LUSEDRA (fospropofol disodium injection) has a pH of 8.2 to 9.0. LUSEDRA (fospropofol disodium injection) does not contain any antimicrobial preservatives and is intended for single-use administration.

Last reviewed on RxList: 2/10/2010
This monograph has been modified to include the generic and brand name in many instances.