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Lymphazurin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 1/3/2016

Lymphazurin 1% (Isosulfan Blue) Aqueous Solution is a contrast agent used to delineate lymphatic vessels draining in the region of injection. Lymphazurin 1% is available in generic form. Common side effects of Lymphazurin 1% include hypersensitivity near the injection site, a temporary blue coloring to the skin, minor allergic reactions such as itching and hives, or serious allergic reactions including respiratory distress and shock.

Lymphazurin 1% is administered subcutaneously, one-half (1/2) ml into three (3) interdigital spaces (spaces between fingers or toes) of each extremity per study. A maximum dose of 3 ml (30 mg) is injected. Lymphazurin may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Lymphazurin should be used only if prescribed. It is unknown if Lymphazurin passes into breast milk. Consult your doctor before breastfeeding.

Our Lymphazurin 1% (Isosulfan Blue) Aqueous Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Lymphazurin FDA Prescribing Information: Side Effects
(Adverse Reactions)


Postmarketing Experience

Hypersensitivity Reactions: Case series report an overall incidence of hypersensitivity reactions in approximately 2% of patients. Life- threatening anaphylactic reactions have occurred. Manifestations include respiratory distress, shock, angioedema, urticaria, pruritus. A death has been reported following administration of a similar compound employed to estimate the depth of a severe burn. Reactions are more likely to occur in patients with a personal or family history of bronchial asthma, significant allergies, drug reactions or previous reactions to triphenylmethane dyes [see WARNINGS and PRECAUTIONS].

Laboratory Tests: Lymphazurin (isosulfan blue) 1% interferes with measurements of oxygen saturation by pulse oximetry and of methemoglobin by gas analyzer [see WARNINGS and PRECAUTIONS].

Skin: transient or long-term (tattooing) blue coloration.

Read the entire FDA prescribing information for Lymphazurin (Isosulfan Blue)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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