Lysodren (Mitotane) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Lysodren

Cancer »

What is cancer?

Cancer is the uncontrolled growth of abnormal cells anywhere in a body. The abnormal cells are termed cancer cells, malignant cells, or tumor cells. Many cancers and the abnormal cells that compose the cancer tissue are further identified by the name of the tissue that the abnormal cells originated from (for example, breast cancer, lung cancer, colon cancer). Cancer is not confined to humans; animals and other living organisms can get cancer. Below is a schematic that shows normal cell division and how when a cell is damaged or altered without repair to its system, the cell usually dies. Also shown is what can occur when such damaged or unrepaired cells do not die and become cancer cells and proliferate with uncontrolled growth; a mass of cancer cells develop. Frequently, cancer cells can break away from this original mass of cells, travel through the blood and lymph systems, and lodge in other organs where they can again repeat the ...

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Lysodren

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LYSODREN®
(mitotane) Tablets, USP

WARNINGS

LYSODREN (mitotane tablets, USP) should be administered under the supervision of a qualified physician experienced in the uses of cancer chemotherapeutic agents. LYSODREN (mitotane) should be temporarily discontinued immediately following shock or severe trauma since adrenal suppression is its prime action. Exogenous steroids should be administered in such circumstances, since the depressed adrenal may not immediately start to secrete steroids.

DRUG DESCRIPTION

LYSODREN® (mitotane tablets, USP) is an oral chemotherapeutic agent. It is best known by its trivial name, o,p'-DDD, and is chemically, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethane. The chemical structure is shown below:

LYSODREN® (mitotane) Structural Formula Illustration

LYSODREN (mitotane) is a white granular solid composed of clear colorless crystals. It is tasteless and has a slight pleasant aromatic odor. It is soluble in ethanol, isooctane and carbon tetrachloride. It has a molecular weight of 320.05.

Inactive ingredients in LYSODREN (mitotane) tablets are: avicel, Polyethylene Glycol 3350, silicon dioxide, and starch.

LYSODREN (mitotane) is available as 500 mg scored tablets for oral administration.

What are the possible side effects of mitotane (Lysodren)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

feeling like you might pass out;
fast or pounding heartbeats;
warmth, redness, or tingly feeling under your skin;
sweating, cold or clammy skin;
high fever, chills, uncontrolled shaking;
blurred or double vision;
confusion, problems...

Read All Potential Side Effects and See Pictures of Lysodren »

What are the precautions when taking mitotane (Lysodren)?

Before taking mitotane, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: current infection (especially viral infections such as chickenpox, herpes), blood pressure problems, liver disease.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication can make it difficult to control your blood pressure. To minimize dizziness and...

Read All Potential Precautions of Lysodren »

Last reviewed on RxList: 3/12/2009
This monograph has been modified to include the generic and brand name in many instances.