"Nov. 29, 2012 (Chicago) -- For cancer patients undergoing chemotherapy who have found their complaints of general mental fogginess and haziness dismissed by their doctors as not being a real medical condition, vindication has arrived.
Mechanism Of Action
Mitotane is an adrenal cytotoxic agent with an unknown mechanism of action. Mitotane modifies the peripheral metabolism of steroids and directly suppresses the adrenal cortex. A reduction in 17-hydroxycorticosteroids in the absence of decreased corticosteroid concentrations and increased formation of 6-β-hydroxycortisol have been reported.
The pharmacodynamics of mitotane are unknown.
Following oral administration of LYSODREN, 40% of the dose is absorbed.
Mitotane is found in most tissues of the body; however, fat is the primary site of distribution.
Following discontinuation of mitotane, the plasma terminal half-life ranges from 18 to 159 days (median 53 days).
Mitotane is converted to a water-soluble metabolite.
No unchanged mitotane is found in urine or bile. Approximately 10% of the administered dose is recovered in the urine as a water-soluble metabolite. A variable amount of metabolite (1%-17%) is excreted in the bile.
Last reviewed on RxList: 3/28/2016
This monograph has been modified to include the generic and brand name in many instances.
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