"The U.S. Food and Drug Administration today approved Zerbaxa (ceftolozane/tazobactam), a new antibacterial drug product, to treat adults with complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI).
(nitrofurantoin monohydrate/macrocrystals) Capsules
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Macrobid and other antibacterial drugs, Macrobid should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Nitrofurantoin is an antibacterial agent specific for urinary tract infections. The Macrobid® brand of nitrofurantoin is a hard gelatin capsule shell containing the equivalent of 100 mg of nitrofurantoin in the form of 25 mg of nitrofurantoin macrocrystals and 75 mg of nitrofurantoin monohydrate.
The chemical name of nitrofurantoin macrocrystals is 1-[[[5-nitro-2-furanyl]methylene] amino]-2,4-imidazolidinedione. The chemical structure is the following:
Molecular Weight: 238.16
The chemical name of nitrofurantoin monohydrate is 1-[[[5-nitro-2-furanyl]methylene] amino]-2,4-imidazolidinedione monohydrate. The chemical structure is the following:
Molecular Weight: 256.17
Inactive Ingredients: Each capsule contains carbomer 934P, corn starch, compressible sugar, D&C Yellow No. 10, edible gray ink, FD&C Blue No. 1, FD&C Red No. 40, gelatin, lactose, magnesium stearate, povidone, talc, and titanium dioxide.
What are the possible side effects of nitrofurantoin (Furadantin, Macrobid, Macrodantin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using nitrofurantoin and call your doctor at once if you have a serious side effect such as:
- diarrhea that is watery or bloody;
- shortness of breath, running out of breath easily;
- sudden chest pain or discomfort, wheezing, dry cough or hack;
- fever, chills, body aches, unexplained weight loss;
- peripheral neuropathy - numbness, tingling, or pain in...
What are the precautions when taking nitrofurantoin (Macrobid)?
Before taking nitrofurantoin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: kidney disease (e.g., little or no urine output), a certain genetic condition (G-6-PD deficiency), a history of liver problems due to nitrofurantoin use in the past.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, lung disease, numbness/tingling of the arms/legs, vitamin B deficiency, mineral...
Last reviewed on RxList: 3/14/2017
This monograph has been modified to include the generic and brand name in many instances.
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