"Urinary tract infection (UTI) facts
- Urinary tract infections (UTIs) are infections of the urethra, bladder, ureters, or the kidneys, which comprise the urinary tract.
- E. coli bacteria cause the majority of UTIs, "...
Macrobid (nitrofurantoin) is indicated only for the treatment of acute uncomplicated urinary tract infections (acute cystitis) caused by susceptible strains of Escherichia coli or Staphylococcus saprophyticus.
Nitrofurantoin is not indicated for the treatment of pyelonephritis or perinephric abscesses.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Macrobid (nitrofurantoin) and other antibacterial drugs, Macrobid (nitrofurantoin) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Nitrofurantoins lack the broader tissue distribution of other therapeutic agents approved for urinary tract infections. Consequently, many patients who are treated with Macrobid (nitrofurantoin) are predisposed to persistence or reappearance of bacteriuria. (See Clinical Studies.) Urine specimens for culture and susceptibility testing should be obtained before and after completion of therapy. If persistence or reappearance of bacteriuria occurs after treatment with Macrobid (nitrofurantoin) , other therapeutic agents with broader tissue distribution should be selected. In considering the use of Macrobid (nitrofurantoin) , lower eradication rates should be balanced against the increased potential for systemic toxicity and for the development of antimicrobial resistance when agents with broader tissue distribution are utilized.
DOSAGE AND ADMINISTRATION
Macrobid (nitrofurantoin) capsules should be taken with food.
Adults and Pediatric Patients Over 12 Years: One 100 mg capsule every 12 hours for seven days.
Macrobid (nitrofurantoin) is available as 100 mg opaque black and yellow capsules imprinted “Macrobid (nitrofurantoin) ” on one half and “Norwich Eaton” on the other.
NDC 0149-0710-01 bottle of 100
Store at controlled room temperature (59° to 86°F or 15° to 30°C).
Meets USP Dissolution Test 2
Mfg. By: Norwich Pharmaceuticals, Inc. North Norwich, NY 13814. Dist by: Procter & Gamble Pharmaceuticals, Inc., TM Owner, Cincinnati, OH 45202. REVISED January 2009
Last reviewed on RxList: 12/2/2010
This monograph has been modified to include the generic and brand name in many instances.
Additional Macrobid Information
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