Macrodantin (Nitrofurantoin Macrocystals Capsule) Drug Information: Medication Guide and Patient Information

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May 27, 2012

Macrodantin

Liver Disease »

What is liver disease?

Liver disease is any disturbance of liver function that causes illness. The liver is responsible for many critical functions within the body and should it become diseased or injured, the loss of those functions can cause significant damage to the body. Liver disease is also referred to as hepatic disease.

Liver disease is a broad term that covers all the potential problems that may occur to cause the liver to fail to perform its designated functions. Usually, more than 75% or three quarters of liver tissue needs to be affected before decrease in function occurs.

The liver the largest solid organ in the body; and is also considered a gland because among its many functions, it makes and secretes bile. The liver is located in the upper right portion of the abdomen protected by the rib cage. It has two main lobes that are made up of tiny lobules. The liver cells have two different sources of blood supply. The hepatic ...

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PATIENT INFORMATION

Patients should be advised to take Macrodantin (nitrofurantoin macrocystals capsule) with food to further enhance tolerance and improve drug absorption. Patients should be instructed to complete the full course of therapy; however, they should be advised to contact their physician if any unusual symptoms occur during therapy.

Many patients who cannot tolerate microcrystalline nitrofurantoin are able to take Macrodantin (nitrofurantoin macrocystals capsule) without nausea.

Patients should be advised not to use antacid preparations containing magnesium trisilicate while taking Macrodantin (nitrofurantoin macrocystals capsule) .

Patients should be counseled that antibacterial drugs including Macrodantin (nitrofurantoin macrocystals capsule) should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Macrodantin (nitrofurantoin macrocystals capsule) is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Macrodantin (nitrofurantoin macrocystals capsule) or other antibacterial drugs in the future.

Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.

Last reviewed on RxList: 4/15/2009
This monograph has been modified to include the generic and brand name in many instances.