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Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated in the following conditions:
Convulsions (treatment) - Intravenous magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children.
Hypomagnesemia (prophylaxis and treatment) - Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia.
Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is also used to prevent or treat magnesium deficiency in patients receiving total parenteral nutrition.
Tetany, uterine (treatment) - Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) is indicated in uterine tetany as a myometrial relaxant.
DOSAGE AND ADMINISTRATION
Intramuscular: Adults and older children: For severe hypomagnesemia, 1 to 5 g (2 to 10 mLof 50% solution) daily in divided doses; administration is repeated daily until serum levels have returned to normal. If deficiency is not severe, 1 g (2 mL of 50% solution) can be given once or twice daily. Serum magnesium levels should serve as a guide to continued dosage.
Intravenous: 1 to 4 g magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) may be given intravenously in 10% to 20% solution, but only with great caution; the rate should not exceed 1.5 mL of 10% solution or equivalent per minute until relaxation is obtained.
Intravenous Infusion: 4 g in 250 mL of 5% Dextrose Injection at a rate not exceeding 3 mL per minute.
Usual Dose Range: 1 to 40 g daily.
Electrolyte Replenisher: Intramuscular 1 to 2 g in 50% solution four times a day until serum magnesium is within normal limits.
Usual Pediatric Dose: Intramuscular 20 to 40 mg per kg of body weight in a 20% solution repeated as necessary.
For Eclampsia: Initially 1 to 2 g in 25% or 50% solution is given intramuscularly. Subsequently, 1 g is given every 30 minutes until relief is obtained. The blood pressure should be monitored after each injection.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
|Product No.||Vial Sizes|
|NDC 0517-2602-25||2 mLSingle Dose Vial||Boxes of 25|
|NDC 0517-2610-25||10 mLSingle Dose Vial||Boxes of 25|
|NDC 0517-2650-25||50 mLSingle Dose Vial||Boxes of 25|
Store at controlled room temperature 15°-30°C (59°-86°F) (See USP).
Discard unused portion.
Manufacturer: n/a. Rev 2/00. FDA Rev date: n/a
Last reviewed on RxList: 8/11/2008
This monograph has been modified to include the generic and brand name in many instances.
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