Makena (Hydroxyprogesterone Caproate Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

Makena

Pregnancy (Stages - Trimesters of Pregnancy) »

Pregnancy facts*

*Pregnancy facts Medically Edited by: Melissa Conrad Stöppler, MD

A normal pregnancy lasts about 40 weeks and is grouped into three trimesters.
Symptoms of early pregnancy include the absence of menstrual periods, breast changes, tiredness, nausea, mood swings, or other symptoms.
A pregnancy test measures the hormone human chorionic gonadotropin in the urine or blood.
Symptoms of late pregnancy can include heartburn, difficulty sleeping, swelling of the ankles or fingers, hemorrhoids, and mild contractions.
By the end of 37 weeks, a baby is considered full term and its organs are ready to function on their own.
As you near your due date, your baby may turn into a head-down position for birth. Most babies "present" head down.
Babies at birth typically weigh between 6 pounds 2 ounces and 9 pounds 2 ounces and are 19 to 21 inches long. M...

Read the Pregnancy (Stages - Trimesters of Pregnancy) article »

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Makena

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MAKENA™
(hydroxyprogesterone caproate) Injection for Intramuscular Use.

DRUG DESCRIPTION

The active pharmaceutical ingredient in Makena is hydroxyprogesterone caproate.

The chemical name for hydroxyprogesterone caproate is pregn-4-ene-3,20-dione, 17[(1-oxohexyl)oxy]. It has an empirical formula of C₂₇H₄₀O₄ and a molecular weight of 428.60. Hydroxyprogesterone caproate exists as white to practically white crystals or powder with a melting point of 120°-124°C.

The structural formula is:

MAKENA (hydroxyprogesterone caproate) Structural Formula - llustration

Makena (hydroxyprogesterone caproate injection) is a clear, yellow, sterile, non-pyrogenic solution for intramuscular injection. Each 5 mL multidose vial contains hydroxyprogesterone caproate USP, 250 mg/mL (25% w/v), in castor oil USP (28.6% v/v) and benzyl benzoate USP (46% v/v) with the preservative benzyl alcohol NF (2% v/v).

What are the precautions when taking hydroxyprogesterone caproate injection (Makena)?

Before using hydroxyprogesterone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, blood clots or other blood clotting problems, cancer (especially of the breast or other female organs), depression, diabetes, severe headaches/migraines, heart problems, high blood pressure, kidney problems, liver problems, seizure disorder, unusual vaginal bleeding, yellowing eyes/skin (jaundice) during pregnancy.

If you have diabetes, this medication may make it harder to control your blood sugar....

Read All Potential Precautions of Makena »

Last reviewed on RxList: 3/29/2011
This monograph has been modified to include the generic and brand name in many instances.