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"On February 3, 2011, the U.S. Food and Drug Administration approved the drug Makena (hydroxyprogesterone caproate) for the reduction of the risk of certain preterm births in women who have had at least one prior preterm birth. KV Pharmaceuticals,"...


Makena Patient Information including If I Miss a Dose

What happens if I miss a dose (Makena)?

Call your doctor for instructions if you miss an appointment for your hydroxyprogesterone injection.

What happens if I overdose (Makena)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving hydroxyprogesterone (Makena)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect hydroxyprogesterone (Makena)?

Tell your doctor about all other medicines you use, especially:

  • acetaminophen (Tylenol);
  • alosetron (Lotronex);
  • betaxolol (Kerlone) or propranolol (Inderal, InnoPran);
  • cyclophosphamide (Gengraf, Neoral, Sandimmune);
  • efavirenz (Sustiva, Atripla);
  • methadone (Methadose, Diskets, Dolophine);
  • mexiletine (Mexitil);
  • nicotine (Nicorette, Commit, Habitrol, Nicotrol, Nicoderm);
  • rifabutin (Mycobutin) or rifampin (Rifater, Rifadin, Rifamate);
  • riluzole (Rilutek);
  • ropinirole (Requip);
  • selegiline (Eldepryl, Emsam, Zelapar);
  • tacrine (Cognex);
  • an antidepressant such as bupropion (Wellbutrin), clomipramine (Anafranil), doxepin (Adapin, Sinequan), duloxetine (Cymbalta), fluvoxamine (Luvox), or mirtazepine (Remeron),
  • asthma medication such as aminophylline (Phyllocontin, Truphylline) or theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
  • cancer medicine such as dacarbazine (DTIC-Dome), flutamide (Eulexin), or irinotecan (Camptosar);
  • medicines to treat psychiatric disorders, such as clozapine (Clozaril, FazaClo), pimozide (Orap), promethazine (Phenergan), thiothixene (Navane), or trifluoperazine (Stelazine); or
  • a muscle relaxer such as cyclobenzaprine (Flexeril) or tizanidine (Zanaflex).

This list is not complete and other drugs may interact with hydroxyprogesterone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about hydroxyprogesterone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 1.01. Revision date: 8/26/2011.

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