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Patients should be instructed:

• to take MALARONE (atovaquone and proguanil hcl) tablets at the same time each day with food or a milky drink.
• to take a repeat dose of MALARONE (atovaquone and proguanil hcl) if vomiting occurs within 1 hour after dosing.
• to take a dose as soon as possible if a dose is missed, then return to their normal dosing schedule. However, if a dose is skipped, the patient should not double the next dose.
• that rare serious adverse events such as hepatitis, severe skin reactions, neurological, and hematological events have been reported when MALARONE (atovaquone and proguanil hcl) was used for the prophylaxis or treatment of malaria.
• to consult a healthcare professional regarding alternative forms of prophylaxis if prophylaxis with MALARONE (atovaquone and proguanil hcl) is prematurely discontinued for any reason.
• that protective clothing, insect repellents, and bednets are important components of malaria prophylaxis.
• that no chemoprophylactic regimen is 100% effective; therefore, patients should seek medical attention for any febrile illness that occurs during or after return from a malaria-endemic area and inform their healthcare professional that they may have been exposed to malaria.
• that falciparum malaria carries a higher risk of death and serious complications in pregnant women than in the general population. Pregnant women anticipating travel to malarious areas should discuss the risks and benefits of such travel with their physicians (see Pregnancy section).

Last reviewed on RxList: 10/7/2009
This monograph has been modified to include the generic and brand name in many instances.