July 29, 2016
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Marcaine Patient Information including How Should I Take

What should I discuss with my health care provider before receiving bupivacaine (Marcaine)?

Tell your doctor if you have ever had an allergic reaction to any type of numbing medicine.

To make sure you can safely receive bupivacaine, tell your doctor if you have any of these other conditions:

  • anemia (lack of red blood cells);
  • kidney or liver disease;
  • a bleeding or blood clotting disorder;
  • syphilis, polio, a brain or spinal cord tumor;
  • numbness or tingling;
  • chronic back pain, headache caused by surgery;
  • low or high blood pressure;
  • curvature of the spine; or
  • arthritis.

FDA pregnancy category C. It is not known whether bupivacaine will harm an unborn baby. Tell your doctor if you are pregnant.

Bupivacaine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using bupivacaine.

How is bupivacaine given (Marcaine)?

Bupivacaine is injected through a needle directly into or near the area to be numbed. You will receive this injection in a dental or hospital setting.

For an epidural, bupivacaine is given as an injection through a needle placed into an area of your middle or lower back near your spine.

For a dental procedure, bupivacaine is injected directly into the mouth near the tooth or teeth your dentist will be working on.

Your breathing, blood pressure, oxygen levels, or other vital signs will be watched closely while you are receiving bupivacaine.

Some epidural numbing medications can have long-lasting or permanent effects on certain body processes such as sexual function, bowel or bladder control, and movement or feeling in your legs or feet. Talk with your doctor about your specific risk of nerve damage from bupivacaine.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Chronic Pain/Back Pain

Find tips and advances in treatment.