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DOSAGE AND ADMINISTRATION
Initially, 2.5 mg MARINOL Capsules should be administered orally twice daily (b.i.d.), before lunch and supper. For patients unable to tolerate this 5 mg/day dosage of MARINOL Capsules, the dosage can be reduced to 2.5 mg/day, administered as a single dose in the evening or at bedtime. If clinically indicated and in the absence of significant adverse effects, the dosage may be gradually increased to a maximum of 20 mg/day MARINOL Capsules, administered in divided oral doses. Caution should be exercised in escalating the dosage of MARINOL Capsules because of the increased frequency of dose-related adverse experiences at higher dosages. (See PRECAUTIONS.)
MARINOL Capsules is best administered at an initial dose of 5 mg/m², given 1 to 3 hours prior to the administration of chemotherapy, then every 2 to 4 hours after chemotherapy is given, for a total of 4 to 6 doses/day. Should the 5 mg/m² dose prove to be ineffective, and in the absence of significant side effects, the dose may be escalated by 2.5 mg/m² increments to a maximum of 15 mg/m² per dose. Caution should be exercised in dose escalation, however, as the incidence of disturbing psychiatric symptoms increases significantly at maximum dose. (See PRECAUTIONS.)
MARINOL Capsules should be packaged in a well-closed container and stored in a cool environment between 8° and 15°C (46° and 59°F) and alternatively could be stored in a refrigerator. Protect from freezing.
MARINOL Capsules (dronabinol solution in sesame oil in soft gelatin capsules)
2.5 mg white capsules (Identified UM). NDC 0051-0021-21 (Bottle of 60 capsules).
5 mg dark brown capsules (Identified UM). NDC 0051-0022-21 (Bottle of 60 capsules).
10 mg orange capsules (Identified UM). NDC 0051-0023-21 (Bottle of 60 capsules).
Manufactured by: Banner Pharmacaps, Inc. High Point, NC 27265. For: AbbVie Inc. North Chicago, IL 60064, U.S.A. Revised: August, 2015This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 2/8/2016
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