Marplan (Isocarboxazid) Patient Information: Missed a Dose and What Should I Avoid at RxList

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May 27, 2012

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Antidepressants are a class of drugs that reduce symptoms of depressive disorders by correcting chemical imbalances of neurotransmitters in the brain. Chemical imbalances may be responsible for changes in mood and behavior.

Neurotransmitters are vital, as they are the communication link between nerve cells in the brain. Neurotransmitters reside within vesicles found in nerve cells, which are released by one nerve and taken up by other nerves. Neurotransmitters not taken up by other nerves are taken up by the same nerves that released them. This process is called "reuptake." The prevalent neurotransmitters in the brain specific to depression are serotonin, dopamine and norepinephrine (also called noradrenaline).

In general, antidepressants work by inhibiting the reuptake of specific neurotransmitters, hence increasing their levels around the nerves within the brain, such...

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Marplan Patient Information including If I Miss a Dose

What happens if I miss a dose (Marplan)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Marplan)?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an isocarboxazid overdose may include shallow breathing, fast heart rate, sweating, fever, slow reflexes, feeling light-headed, fainting, or seizure (convulsions).

What should I avoid while taking isocarboxazid (Marplan)?

While you are taking isocarboxazid you must not eat foods that are high in tyramine, including:

cheese (especially strong or aged cheeses);
sour cream;
beer (including non-alcoholic beer), sherry, Chianti wine, liquers;
dry sausage (such as hard salami, pepperoni, anchovies, caviar, liver, pickled herring;
canned figs, raisins, bananas;
avocados;
chocolate or caffeine;
soy sauce;
sauerkraut;
fava beans;
yeast extracts;
yogurt;
meat extracts;
meat prepared with tenderizer; or
over-the-counter supplements or cough and cold medicines that contain dextromethorphan or tyramine.

You should become very familiar with the list of foods and medicines you must avoid while you are taking isocarboxazid. Eating tyramine while you are taking isocarboxazid can raise your blood pressure to dangerous levels which could cause life-threatening side effects.

Isocarboxazid can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What other drugs will affect isocarboxazid (Marplan)?

There are many other medicines that can cause serious or life-threatening medical problems if you take them together with isocarboxazid. Do not take isocarboxazid before telling your doctor about all other prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor, dentist, or other healthcare provider who treats you.

Where can I get more information?

Your pharmacist has more information about isocarboxazid written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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