July 23, 2016
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Marplan Patient Information including How Should I Take

What should I discuss with my doctor before taking isocarboxazid (Marplan)?

Do not use this medication if you have used another MAOI such as phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take isocarboxazid before another MAOI has cleared from your body.

Do not take this medication if you are allergic to isocarboxazid, or if you have:

  • pheochromocytoma (tumor of the adrenal gland);
  • a history of stroke or blood clots;
  • liver disease;
  • kidney disease;
  • heart disease;
  • high blood pressure; or
  • a history of severe or frequent headaches.

There are many other medicines that can cause serious or life-threatening medical problems if you take them together with isocarboxazid. The following drugs should not be used while you are taking isocarboxazid:

  • diet pills, caffeine, stimulants, ADHD medication, asthma medication, over-the-counter cough and cold or allergy medicines;
  • blood pressure medication;
  • diuretics (water pills);
  • bupropion (Wellbutrin, Zyban);
  • buspirone (BuSpar);
  • carbamazepine (Carbatrol, Tegretol);
  • furazolidone (Furoxone);
  • meperidine (Demerol, Mepergan);
  • pargyline (Eutonyl);
  • procarbazine (Matulane);
  • alcohol or medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety).
  • antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adepin, Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil); or
  • antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).

If you have any of these other conditions, you may need an isocarboxazid dose adjustment or special tests:

  • high blood pressure;
  • diabetes;
  • a thyroid disorder;
  • schizophrenia;
  • epilepsy or other seizure disorder;
  • if you have taken another antidepressant within the past 5 weeks; or
  • if you are also taking tryptophan (L-tryptophan), guanethidine (Ismelin), levodopa (Larodopa, Parcopa, Sinemet), or methyldopa (Aldomet).

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. It is not known whether isocarboxazid will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether isocarboxazid passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give isocarboxazid to anyone younger than 16 years old without the advice of a doctor.

How should I take isocarboxazid (Marplan)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Your blood pressure will need to be tested often. Visit your doctor regularly.

Take this medication for the entire length of time prescribed by your doctor. It may take up to 6 weeks or longer before you notice improvement in your symptoms.

Store at room temperature away from moisture and heat.

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Marplan - User Reviews

Marplan User Reviews

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