Mate

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Are there any interactions with medications?



Amphetamines
Interaction Rating: Major Do not take this combination.

Stimulant drugs such as amphetamines speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and increase your heart rate. The caffeine in mate might also speed up the nervous system. Taking mate along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with mate.



Cocaine
Interaction Rating: Major Do not take this combination.

Stimulant drugs such as cocaine speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and increase your heart rate. The caffeine in mate might also speed up the nervous system. Taking mate along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with mate.



Ephedrine
Interaction Rating: Major Do not take this combination.

Stimulant drugs speed up the nervous system. Caffeine (contained in mate) and ephedrine are both stimulant drugs. Taking caffeine along with ephedrine might cause too much stimulation and sometimes serious side effects and heart problems. Do not take caffeine-containing products and ephedrine at the same time.



Adenosine (Adenocard)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Mate contains caffeine. The caffeine in mate might block the effects of adenosine (Adenocard). Adenosine (Adenocard) is often used by doctors to do a test on the heart. This test is called a cardiac stress test. Stop consuming mate or other caffeine-containing products at least 24 hours before a cardiac stress test.



Antibiotics (Quinolone antibiotics)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down caffeine to get rid of it. Some antibiotics might decrease how quickly the body breaks down caffeine. Taking these antibiotics along with mate can increase the risk of side effects including jitteriness, headache, increased heart rate, and other side effects.

Some antibiotics that decrease how quickly the body breaks down caffeine include ciprofloxacin (Cipro), enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).



Cimetidine (Tagamet)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Mate contains caffeine. The body breaks down caffeine to get rid of it. Cimetidine (Tagamet) can decrease how quickly your body breaks down caffeine. Taking cimetidine (Tagamet) along with mate might increase the chance of caffeine side effects including jitteriness, headache, fast heartbeat, and others.



Clozapine (Clozaril)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down clozapine (Clozaril) to get rid of it. The caffeine in mate seems to decrease how quickly the body breaks down clozapine (Clozaril). Taking mate along with clozapine (Clozaril) can increase the effects and side effects of clozapine (Clozaril).



Dipyridamole (Persantine)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Mate contains caffeine. The caffeine in mate might block the effects of dipyridamole (Persantine). Dipyridamole (Persantine) is often used by doctors to do a test on the heart. This test is called a cardiac stress test. Stop consuming mate or other caffeine-containing products at least 24 hours before a cardiac stress test.



Disulfiram (Antabuse)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down caffeine to get rid of it. Disulfiram (Antabuse) can decrease how quickly the body gets rid of caffeine. Taking mate (which contains caffeine) along with disulfiram (Antabuse) might increase the effects and side effects of caffeine including jitteriness, hyperactivity, irritability, and others.



Estrogens
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down caffeine (contained in mate) to get rid of it. Estrogens can decrease how quickly the body breaks down caffeine. Decreasing the breakdown of caffeine can cause jitteriness, headache, fast heartbeat, and other side effects. If you take estrogens, limit your caffeine intake.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.



Fluvoxamine (Luvox)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down the caffeine in mate to get rid of it. Fluvoxamine (Luvox) can decrease how quickly the body breaks down caffeine. Taking mate along with fluvoxamine (Luvox) might cause too much caffeine in the body, and increase the effects and side effects of mate.



Lithium
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Your body naturally gets rid of lithium. The caffeine in mate can increase how quickly your body gets rid of lithium. If you take products that contain caffeine and you take lithium, stop taking caffeine products slowly. Stopping mate too quickly can increase the side effects of lithium.



Medications for asthma (Beta-adrenergic agonists)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Mate contains caffeine. Caffeine can stimulate the heart. Some medications for asthma can also stimulate the heart. Taking caffeine with some medications for asthma might cause too much stimulation and cause heart problems.

Some medications for asthma include albuterol (Proventil, Ventolin, Volmax), metaproterenol (Alupent), terbutaline (Bricanyl, Brethine), and isoproterenol (Isuprel).



Medications for depression (MAOIs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The caffeine in mate can stimulate the body. Some medications used for depression can also stimulate the body. Drinking mate and taking some medications for depression might cause too much stimulation to the body and serious side effects including fast heartbeat, high blood pressure, nervousness, and others could occur.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.



Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Mate contains caffeine. Caffeine might slow blood clotting. Taking mate along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



Nicotine
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Stimulant drugs such as nicotine speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and increase your heart rate. The caffeine in mate might also speed up the nervous system. Taking mate along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with mate.



Pentobarbital (Nembutal)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The stimulant effects of the caffeine in mate can block the sleep-producing effects of pentobarbital.



Phenylpropanolamine
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Mate contains caffeine. Caffeine can stimulate the body. Phenylpropanolamine can also stimulate the body. Taking mate and phenylpropanolamine together might cause too much stimulation and increase heartbeat and blood pressure and cause nervousness.



Riluzole (Rilutek)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down riluzole (Rilutek) to get rid of it. Taking mate can decrease how fast the body breaks down riluzole (Rilutek) and increase the effects and side effects of riluzole.



Theophylline
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Mate contains caffeine. Caffeine works similarly to theophylline. Caffeine can also decrease how quickly the body gets rid of theophylline. Taking mate along with theophylline might increase the effects and side effects of theophylline.



Verapamil (Calan, Covera, Isoptin, Verelan)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down the caffeine in mate to get rid of it. Verapamil (Calan, Covera, Isoptin, Verelan) can decrease how quickly the body gets rid of caffeine. Drinking mate and taking verapamil (Calan, Covera, Isoptin, Verelan) can increase the risk of side effects for caffeine including jitteriness, headache, and an increased heartbeat.



Alcohol
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

The body breaks down the caffeine in mate to get rid of it. Alcohol can decrease how quickly the body breaks down caffeine. Taking mate along with alcohol might cause too much caffeine in the bloodstream and caffeine side effects including jitteriness, headache, and fast heartbeat.



Birth control pills (Contraceptive drugs)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

The body breaks down the caffeine in mate to get rid of it. Birth control pills can decrease how quickly the body breaks down caffeine. Taking mate along with birth control pills can cause jitteriness, headache, fast heartbeat, and other side effects.

Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.



Fluconazole (Diflucan)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Mate contains caffeine. The body breaks down caffeine to get rid of it. Fluconazole (Diflucan) might decrease how quickly the body gets rid of caffeine. This could cause caffeine to stay in the body too long and increase the risk of side effects such as nervousness, anxiety, and insomnia.



Medications for diabetes (Antidiabetes drugs)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Mate might increase blood sugar. Diabetes medications are used to lower blood sugar. By increasing blood sugar, mate might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.



Mexiletine (Mexitil)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Mate contains caffeine. The body breaks down caffeine to get rid of it. Mexiletine (Mexitil) can decrease how quickly the body breaks down caffeine. Taking Mexiletine (Mexitil) along with mate might increase the caffeine effects and side effects of mate.



Terbinafine (Lamisil)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

The body breaks down caffeine (contained in mate) to get rid of it. Terbinafine (Lamisil) can decrease how fast the body gets rid of caffeine and increase the risk of side effects including jitteriness, headache, increased heartbeat, and other effects.

Dosing considerations for Mate.

The appropriate dose of mate depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for mate. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


Therapeutic Research Faculty copyright

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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