Matulane (Procarbazine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

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Matulane

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MATULANE®
(procarbazine hydrochloride) Capsules

WARNING

It is recommended that MATULANE (procarbazine) be given only by or under the supervision of a physician experienced in the use of potent antineoplastic drugs. Adequate clinical and laboratory facilities should be available to patients for proper monitoring of treatment.

DRUG DESCRIPTION

Matulane (procarbazine hydrochloride), a hydrazine derivative antineoplastic agent, is available as capsules containing the equivalent of 50 mg procarbazine as the hydrochloride. Each capsule also contains cornstarch, mannitol and talc. Gelatin capsule shells contain parabens (methyl and propyl), potassium sorbate, titanium dioxide, FD&C Yellow No. 6 and D&C Yellow No. 10.

Chemically, procarbazine hydrochloride is N-isopropyl-α-(2-methylhydrazino)-p-toluamide monohydrochloride. It is a white to pale yellow crystalline powder which is soluble but unstable in water or aqueous solutions. The molecular weight of procarbazine hydrochloride is 257.76 and the structural formula is:

Matulane (procarbazine hydrochloride) structural formula illustration

What are the possible side effects of procarbazine (Matulane)?

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);
decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
numbness, tingling, or confusion;
any sore in or around the...

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What are the precautions when taking procarbazine (Matulane)?

Before taking procarbazine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of alcohol use.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart/blood vessel problems, recent chickenpox, shingles (Herpes zoster), diabetes, seizures, liver disease, kidney disease, severe/frequent headaches, current infection, overactive thyroid (hyperthyroidism), current or past tobacco use,...

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Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.