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In this Article

• What is procarbazine (Matulane)?
• What are the possible side effects of procarbazine (Matulane)?
• What is the most important information I should know about procarbazine (Matulane)?
• What should I discuss with my healthcare provider before taking procarbazine (Matulane)?
• How should I take procarbazine (Matulane)?
• What happens if I miss a dose (Matulane)?
• What happens if I overdose (Matulane)?
• What should I avoid while taking procarbazine (Matulane)?
• What other drugs will affect procarbazine (Matulane)?
• Where can I get more information?

What should I discuss with my healthcare provider before taking procarbazine (Matulane)?

Before taking procarbazine, tell your doctor if you have:

• kidney disease;
• liver disease;
• bone marrow problems; or
• glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.

You may not be able to take procarbazine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Procarbazine is in the FDA pregnancy category D. This means that procarbazine is known to cause birth defects in an unborn baby. Procarbazine may also affect egg production in women and sperm production in men. Do not take procarbazine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Contraceptive measures are recommended during treatment with procarbazine.

It is not known whether procarbazine passes into breast milk. Do not take procarbazine without first talking to your doctor if you are breast feeding a baby.

How should I take procarbazine (Matulane)?

Take procarbazine exactly as directed by your doctor. If you do not understand these instructions, as your doctor, nurse or pharmacist to explain them to you.

Take each oral dose with a large glass of water.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with procarbazine to monitor progress and side effects.

Store procarbazine tablets at room temperature away from heat and moisture. Keep this product out of the reach of children.