In this Article

• What is procarbazine (Matulane)?
• What are the possible side effects of procarbazine (Matulane)?
• What is the most important information I should know about procarbazine (Matulane)?
• What should I discuss with my healthcare provider before taking procarbazine (Matulane)?
• How should I take procarbazine (Matulane)?
• What happens if I miss a dose (Matulane)?
• What happens if I overdose (Matulane)?
• What should I avoid while taking procarbazine (Matulane)?
• What other drugs will affect procarbazine (Matulane)?
• Where can I get more information?

What should I discuss with my healthcare provider before taking procarbazine (Matulane)?

You should not take procarbazine if you are allergic to it, or if you have bone marrow suppression.

To make sure you can safely use procarbazine, tell your doctor if you have any of these other conditions:

• kidney disease;
• liver disease;
• anemia (low red blood cells);
• low levels of platelets in the blood;
• low white blood cell counts;
• fluid retention; or
• if you have received other cancer medications or radiation within the past 30 days.

FDA pregnancy category D. Do not use procarbazine if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Procarbazine can lower sperm count in men, which may affect fertility (your ability to have children).

It is not known whether procarbazine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking procarbazine.

How should I take procarbazine (Matulane)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Procarbazine can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Avoid activities that may increase your risk of bleeding or injury.

To make sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Do not miss any follow-up visits to your doctor.

Store at room temperature away from moisture and heat.