February 14, 2016
Recommended Topic Related To:


"SAN FRANCISCO ” Tumor-treating fields (TTFields, Novocure) therapy, already approved for use in glioblastoma, has now shown benefit in patients with advanced pancreatic cancer.

TTFields combined with gemcitabine (Gemzar, Lill"...



Side Effects


Leukopenia, anemia and thrombopenia occur frequently. Nausea and vomiting are the most commonly reported side effects.

Other adverse reactions are:

Hematologic: Pancytopenia; eosinophilia; hemolytic anemia; bleeding tendencies such as petechiae, purpura, epistaxis and hemoptysis.

Gastrointestinal: Hepatic dysfunction, jaundice, stomatitis, hematemesis, mele-na, diarrhea, dysphagia, anorexia, abdominal pain, constipation, dry mouth.

Neurologic: Coma, convulsions, neuropathy, ataxia, paresthesia, nystagmus, diminished reflexes, falling, foot drop, headache, dizziness, unsteadiness.

Cardiovascular: Hypotension, tachycardia, syncope.

Ophthalmic: Retinal hemorrhage, papilledema, photophobia, diplopia, inability to focus.

Respiratory: Pneumonitis, pleural effusion, cough.

Dermatologic: Herpes, dermatitis, pruritus, alopecia, hyperpigmentation, rash, urticaria, flushing.

Allergic: Generalized allergic reactions.

Genitourinary: Hematuria, urinary frequency, nocturia.

Musculoskeletal: Pain, including myalgia and arthralgia; tremors.

Psychiatric: Hallucinations, depression, apprehension, nervousness, confusion, nightmares.

Endocrine: Gynecomastia in prepubertal and early pubertal boys.

Miscellaneous: Intercurrent infections, hearing loss, pyrexia, diaphoresis, lethargy, weakness, fatigue, edema, chills, insomnia, slurred speech, hoarseness, drowsiness.

Second nonlymphoid malignancies, (including lung cancer, acute myelocytic leukemia and malignant myelosclerosis), and azoospermia have been reported in patients with Hodgkin's disease treated with procarbazine in combination with other chemotherapy and/or radiation. The risks of secondary lung cancer from treatment appear to be multiplied by tobacco use.

Read the Matulane (procarbazine) Side Effects Center for a complete guide to possible side effects


See WARNINGS section.

No cross-resistance with other chemotherapeutic agents, radiotherapy or steroids has been demonstrated.

Read the Matulane Drug Interactions Center for a complete guide to possible interactions

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/29/2008

Side Effects

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