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Matulane Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Matulane (procarbazine hydrochloride) Capsules is a cancer medication that is given with other cancer medications to treat Hodgkin's Disease (a type of blood cancer). Common side effects of Matulane include nausea and vomiting (may be severe), loss of appetite, stomach pain, constipation, dry mouth, diarrhea, difficulty swallowing, drowsiness, tiredness, dizziness, headache, trouble sleeping, muscle or joint pain, temporary hair loss, darkening of the skin, itching or rash, urinating more than usual, or changes in your menstrual periods.
All dosages of Matulane are based on the patient's actual weight. The recommended adult starting dose of Matulane is single or divided doses of 2 to 4 mg/kg/day for the first week. Matulane may interact with blood pressure medications, antidepressants, barbiturates, diet pills, stimulants, or ADHD medications, phenothiazines, or other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). Tell your doctor all medications and supplements you use. Matulane is not recommended for use during pregnancy. It may harm a fetus. It is recommended that men and women use 2 forms of birth control (e.g., condoms and birth control pills) while being treated with this medication and for some time afterward. Consult your doctor to discuss birth control. It is unknown if this drug passes into breast milk. Because this drug may harm a nursing infant, breastfeeding while using this drug is not recommended.
Our Matulane (procarbazine hydrochloride) Capsules Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Matulane in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- diarrhea that is watery;
- feeling like you might pass out;
- numbness, burning pain, or tingly feeling;
- confusion, hallucinations, problems with vision or speech, trouble with walking or daily activities;
- feeling unsteady, loss of balance or coordination;
- tremors, seizure (convulsions);
- cough, chest pain, trouble breathing;
- fever, chills, body aches, flu symptoms;
- easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- white patches or sores inside your mouth or on your lips;
- jaundice (yellowing of the skin or eyes);
- black, bloody, or tarry stools; or
- coughing up blood or vomit that looks like coffee grounds.
Less serious side effects may include:
- mild nausea, vomiting, loss of appetite, stomach pain;
- dry mouth, constipation, mild diarrhea;
- mild itching or rash, temporary hair loss;
- muscle of joint pain;
- headache, dizziness, feeling tired;
- urinating more than usual; or
- changes in your menstrual periods.
Read the entire detailed patient monograph for Matulane (Procarbazine)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Matulane Overview - Patient Information: Side Effects
Temporary hair loss may occur. Normal hair growth should return several months after treatment has ended.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Some people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: black/bloody stools, bloody/pink urine, vomit that is bloody or looks like coffee grounds, stomach pain, yellowing eyes/skin, unsteadiness, fainting.
Seek immediate medical attention if any of these unlikely but very serious side effects occur: chest pain, vision problems, fast or slow heartbeat, severe headache, seizures, stiff/sore neck, increased sweating (with or without fever), cold/clammy skin, mental/mood changes, tingling/numbness of hands/feet, unusual bleeding/bruising, diarrhea, mouth/lip sores.
This medication can lower your body's ability to fight an infection. Tell your doctor if you develop any signs of an infection such as: fever, sore throat, chills, unusual tiredness, lower back or side pain, difficult urination, cough, breathing difficulty, thick mucus/phlegm.
This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.
Very rarely, people with cancer who are treated with this type of medication have developed other cancers (e.g., secondary leukemia). Your risk is greater if you have received certain types of chemotherapy or radiation therapy. Consult your doctor for more details.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Matulane (Procarbazine)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Matulane FDA Prescribing Information: Side Effects
Other adverse reactions are:
Pneumonitis, pleural effusion, cough.
Generalized allergic reactions.
Hallucinations, depression, apprehension, nervousness, confusion, nightmares.
Second nonlymphoid malignancies (including lung cancer, acute myelocytic leukemia and malignant myelosclerosis) and azoospermia have been reported in patients with Hodgkin's disease treated with procarbazine in combination with other chemotherapy and/or radiation. The risks of secondary lung cancer from treatment appear to be multiplied by tobacco use.
Read the entire FDA prescribing information for Matulane (Procarbazine)
Additional Matulane Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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