"What are ACE inhibitors and how do they work?
The class of drugs called angiotensin converting enzyme (ACE) inhibitors, as the class name suggests, reduces the activity of angiotensin converting enzyme. ACE converts angiotensin I pr"...
- When pregnancy is detected, discontinue MAVIK as soon as possible.
- Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (See WARNINGS: Fetal Toxicity).
Trandolapril is the ethyl ester prodrug of a nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, trandolaprilat. Trandolapril is chemically described as (2S, 3aR, 7aS)-1-[(S)-N-[(S)-1Carboxy-3-phenylpropyl]alanyl] hexahydro-2-indolinecarboxylic acid, 1-ethyl ester. Its empirical formula is C24H34N2O5 and its structural formula is
M.W. = 430.54
Melting Point = 125°C
Trandolapril is a white or almost white powder that is soluble ( > 100 mg/mL) in chloroform, dichloromethane, and methanol. MAVIK tablets contain 1 mg, 2 mg, or 4 mg of trandolapril for oral administration. Each tablet also contains corn starch, croscarmellose sodium, hypromellose, iron oxide, lactose monohydrate, povidone, sodium stearyl fumarate.
What are the possible side effects of trandolapril (Mavik)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Call your doctor at once if you have a serious side effect such as:
- urinating less than usual, or not at all;
- swelling, weight gain, feeling short of breath;
- feeling like you might pass out;
- chest pain, trouble breathing;
- pounding heartbeats or fluttering in your chest;
- fever, chills, body...
What are the precautions when taking trandolapril (Mavik)?
Before taking trandolapril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (e.g., benazepril, captopril); or if you have any other allergies (including exposure to certain membranes used for blood filtering). This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, high blood levels of...
Last reviewed on RxList: 4/6/2016
This monograph has been modified to include the generic and brand name in many instances.
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