Maxide (Triamterene and Hydrochlorothiazide Tablets) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

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High blood pressure facts

High blood pressure (hypertension) is designated as either essential (primary) hypertension or secondary hypertension and is defined as a consistently elevated blood pressure exceeding 140/90 mm Hg.
High blood pressure is called "the silent killer" because it often causes no symptoms for many years, even decades, until it finally damages certain critical organs.
Poorly controlled high blood pressure ultimately can cause damage to blood vessels in the eye, thickening of the heart muscle and heart attacks, hardening of the arteries (arteriosclerosis), kidney failure, and strokes.
Most antihypertensive medications can be used alone or in combination. Some are used only in combination. Some are preferred over others in certain specific medical situations. And some are not to be used (contraindicated) in other situations.
Several classes of antihypertensive medications are available, including ACE i...

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MAXZIDE®
(triamterene and hydrochlorothiazide) Tablets, USP) 75 mg/50 mg

MAXZIDE®-25 MG
(triamterene and hydrochlorothiazide) Tablets, USP) 37.5 mg/25 mg

DRUG DESCRIPTION

MAXZIDE® (triamterene and hydrochlorothiazide) combines triamterene, a potassium-conserving diuretic, with the natriuretic agent, hydrochlorothiazide.

Each MAXZIDE® (triamterene and hydrochlorothiazide tablets) tablet contains:

Triamterene, USP ........................................ 75 mg
Hydrochlorothiazide, USP ............................ 50 mg

Each MAXZIDE® (triamterene and hydrochlorothiazide tablets) -25 MG tablet contains:

Triamterene, USP ......................................... 37.5 mg
Hydrochlorothiazide, USP ............................. 25 mg

MAXZIDE® (triamterene and hydrochlorothiazide tablets) and MAXZIDE® (triamterene and hydrochlorothiazide tablets) -25 MG tablets for oral administration contain the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, D&C Yellow No. 10 Aluminum Lake, magnesium stearate, microcrystalline cellulose, powdered cellulose and sodium lauryl sulfate. MAXZIDE® (triamterene and hydrochlorothiazide tablets) -25 MG tablets also contain FD&C Blue No. 1 Aluminum Lake.

Triamterene is 2,4,7-triamino-6-phenylpteridine. Triamterene is practically insoluble in water, benzene, chloroform, ether and dilute alkali hydroxides. It is soluble in formic acid and sparingly soluble in methoxyethanol. Triamterene is very slightly soluble in acetic acid, alcohol and dilute mineral acids. Its molecular weight is 253.27. Its structural formula is:

Triamterene Structural Formula Illustration

Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4, benzothiadiazine-7-sulfonamide 1,1-dioxide. Hydrochlorothiazide is slightly soluble in water and freely soluble in sodium hydroxide solution, n-butylamine and dimethylformamide. It is sparingly soluble in methanol and insoluble in ether, chloroform and dilute mineral acids. Its molecular weight is 297.73. Its structural formula is: