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Maxide

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Maxide

Maxide Side Effects Center

Medical Editor: Melissa Conrad Stöppler, MD

Maxide (triamterene and hydrochlorothiazide) is a combination of two drugs and is prescribed as a treatment for hypertension (high blood pressure) and edema. Maxide is also a diuretic given to patients who cannot risk low blood potassium. Maxide may be used alone or in combination with other antihypertensive drugs, such as beta-blockers but dosages may need to be adjusted; regardless, potassium levels in patients is recommended for all patients taking Maxide. Generic Maxide is named triamterene/hydrochlorothiazide or triamterene/HCTZ. Side effects of Maxide can include nausea, diarrhea, constipation, fatigue, headache, insomnia, and dry mouth.

Maxide has two preparations based on the strengths of the two components; triamterene and hydrochlorothiazide at concentrations of 37.5 and 25 mg or 75 and 50 mg, respectively. The usual dose of Maxide is 25mg based on the hydrochlorothiazide concentration, one or two tablets daily, given as a single dose. Divided daily doses, (rather than a single daily dose, and not recommend by the supplier) may place patients at an increased risk of electrolyte imbalance and kidney dysfunction. Other serious side effects include jaundice, hyperkalemia, hypokalemia, hyper and hyponatremia, acute renal failure, hemolytic anemia, allergic reactions and other electrolyte abnormalities. The routine use of this and other diuretics in an otherwise healthy pregnant woman to reduce minor dependent edema or in an attempt to prevent toxemia of pregnancy is inappropriate and exposes mother and fetus to unnecessary hazards. The safe use of Maxide in pregnancy has not been established and the effect of Maxide in pregnant women has not been studied. Maxide should be used during pregnancy only if the potential benefit justifies the risk to the fetus. If use of Maxide is deemed essential, breastfeeding mothers should stop nursing because some of the drug is found in breast milk. Maxide has not been studied in children.

Our Maxide (triamterene and hydrochlorothiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Maxide FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Side effects observed in association with the use of MAXZIDE, other combination products containing triamterene/hydrochlorothiazide, and products containing triamterene or hydrochlorothiazide include the following:

Gastrointestinal: jaundice (intrahepatic cholestatic jaundice), pancreatitis, nausea, appetite disturbance, taste alteration, vomiting, diarrhea, constipation, anorexia, gastric irritation, cramping.

Central Nervous System: drowsiness and fatigue, insomnia, headache, dizziness, dry mouth, depression, anxiety, vertigo, restlessness, paresthesias.

Cardiovascular: tachycardia, shortness of breath and chest pain, orthostatic hypotension (may be aggravated by alcohol, barbiturates or narcotics).

Renal: acute renal failure, acute interstitial nephritis, renal stones composed of triamterene in association with other calculus materials, urine discoloration.

Hematologic: leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia and megaloblastosis.

Ophthalmic: xanthopsia, transient blurred vision.

Hypersensitivity: anaphylaxis, photosensitivity, rash, urticaria, purpura, necrotizing angiitis (vasculitis, cutaneous vasculitis), fever, respiratory distress including pneumonitis.

Other: muscle cramps and weakness, decreased sexual performance and sialadenitis.

Whenever adverse reactions are moderate to severe, therapy should be reduced or withdrawn.

Altered Laboratory Findings

Serum Electrolytes: hyperkalemia, hypokalemia, hyponatremia, hypomagnesemia, hypochloremia (see WARNINGS and PRECAUTIONS).

Creatinine, Blood Urea Nitrogen: Reversible elevations in BUN and serum creatinine have been observed in hypertensive patients treated with MAXZIDE.

Glucose: hyperglycemia, glycosuria and diabetes mellitus (see PRECAUTIONS).

Serum Uric Acid, PBI and Calcium: (see PRECAUTIONS).

Other: Elevated liver enzymes have been reported in patients receiving MAXZIDE.

Read the entire FDA prescribing information for Maxide (Triamterene and Hydrochlorothiazide Tablets) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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