Maxipime (Cefepime Hydrochloride for Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Maxipime

Urinary Tract Infection (UTI In Adults) »

Urinary tract infection (UTI) facts

Urinary tract infections (UTIs) are infections of the urethra, bladder, ureters, or the kidneys, which comprise the urinary tract.
E. coli bacteria cause the majority of UTIs, but many other bacteria, fungi, and parasites may also cause UTIs.
Females have a higher risk for UTIs than most males, probably because of their anatomy; other risk factors for UTIs include any condition that may impede urine flow (e.g., enlarged prostate, congenital urinary tract abnormalities, and inflammation). Patients with catheters or those who undergo urinary surgery and men with enlarged prostates are at higher risk for UTIs.
Symptoms and signs of UTI vary somewhat depending on sex, age, and the area of the urinary tract that is infected; some unique symptoms develop depending on the infecting agent.
UTIs are diagnosed usually by isolating and identifying the urinary pathogen from the patient; there a...

Read the Urinary Tract Infection (UTI In Adults) article »

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Maxipime

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MAXIPIME®
(cefepime hydrochloride, USP) for Injection

For Intravenous or Intramuscular Use

To reduce the development of drug-resistant bacteria and maintain the effectiveness of MAXIPIME® (cefepime hydrochloride for injection) and other antibacterial drugs, MAXIPIME (cefepime hydrochloride for injection) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

DRUG DESCRIPTION

MAXIPIME (cefepime hydrochloride, USP) is a semi-synthetic, broad spectrum, cephalosporin antibiotic for parenteral administration. The chemical name is 1-[[(6R,7R)-7-[2-(2-amino-4-thiazolyl)-glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl]methyl]-1-methylpyrrolidinium chloride, 7²-(Z)-(O-methyloxime), monohydrochloride, monohydrate, which corresponds to the following structural formula:

MAXIPIME® (cefepime hydrochloride for injection)
(Cefepime Hydrochloride) Structural Formula Illustration

Cefepime hydrochloride is a white to pale yellow powder. Cefepime hydrochloride contains the equivalent of not less than 825 mcg and not more than 911 mcg of cefepime (C₁₉H₂₄N₆O₅S₂) per mg, calculated on an anhydrous basis. It is highly soluble in water.

MAXIPIME (cefepime hydrochloride for injection) for Injection is supplied for intramuscular or intravenous administration in strengths equivalent to 500 mg, 1 g, and 2 g of cefepime. (See DOSAGE AND ADMINISTRATION.) MAXIPIME (cefepime hydrochloride for injection) is a sterile, dry mixture of cefepime hydrochloride and L-arginine. It contains the equivalent of not less than 90 percent and not more than 115 percent of the labeled amount of cefepime (C₁₉H₂₄N₆O₅S₂). The L-arginine, at an approximate concentration of 725 mg/g of cefepime, is added to control the pH of the constituted solution at 4.0–6.0. Freshly constituted solutions of MAXIPIME (cefepime hydrochloride for injection) will range in color from colorless to amber.

What are the possible side effects of cefepime (Maxipime)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

confusion, hallucinations, or convulsiones o se desmaya. seizure (black-out or convulsions);
diarrhea that is watery or bloody;
skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
fever, chills, body aches, flu symptoms;
easy bruising...

Read All Potential Side Effects and See Pictures of Maxipime »

What are the precautions when taking cefepime hydrochloride for injection (Maxipime)?

Before using cefepime, tell your doctor or pharmacist if you are allergic to it; or to other cephalosporins; or to penicillins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, stomach/intestinal diseases (e.g., colitis).

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.

Tell your doctor if you are pregnant before using this medication.

This medication passes into breast milk and may have...

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Last reviewed on RxList: 10/13/2009
This monograph has been modified to include the generic and brand name in many instances.