Maxitrol (Neomycin, Polymyxin B and Dexamethasone Ophthalmic) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

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Maxitrol

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Maxitrol
(neomycin and polymyxin B sulfates and dexamethasone) Ophthalmic Suspension Sterile

DRUG DESCRIPTION

MAXITROL (neomycin and polymyxin B sulfates and dexamethasone ophthalmic suspension) is a multiple dose anti-infective steroid combination in sterile suspension form for topical application. The chemical structure for the active ingredient, dexamethasone, is:

Dexamethasone structural formula illustration

Established name: dexamethasone

Chemical name: pregna-1, 4-diene-3, 20-dione, 9-fluoro-11, 17, 21-trihydroxy-16-methyl-, (11β, 16α)-. MW = 392.45

The other active ingredients are neomycin sulfate and polymyxin B sulfate. The structural formula for neomycin sulfate is:

Neomycin sulfate structural formula illustration

The structural formula for polymyxin B sulfate is:

[structure]

Each mL contains: Actives: neomycin sulfate equivalent to neomycin 3.5 mg, polymyxin B sulfate 10,000 units, dexamethasone 0.1 %. Inactives: hypromellose 2910 0.5%, sodium chloride, polysorbate 20, hydrochloric acid and/or sodium hydroxide (to adjust pH), purified water, benzalkonium chloride 0.004% (preservative).

What are the possible side effects of neomycin, polymyxin B and dexamethasone ophthalmic (Maxitrol, Ocu-Trol, Poly-Dex)?

Serious side effects are not expected with this medication.

Some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

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What are the precautions when taking neomycin, polymyxin b and dexamethasone ophthalmic (Maxitrol)?

Before using this medication, tell your doctor or pharmacist if you are allergic to neomycin, polymyxin, or dexamethasone; or to aminoglycoside antibiotics (e.g., gentamicin, tobramycin); or to corticosteroids (e.g., hydrocortisone, prednisone); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e.g., glaucoma).

After you apply this drug, your vision may become temporarily unstable. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you...

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Last reviewed on RxList: 8/27/2008
This monograph has been modified to include the generic and brand name in many instances.