MDP Multidose Kit

CLINICAL PHARMACOLOGY

During the initial 24 hours following intravenous injection of technetium Tc99m medronate about 50% of each dose is retained in the skeleton, and about 50% of each dose is excreted into the bladder.

Within 3 hours bone uptake is about 40-50% of each dose. Clearance of the complex from the blood is rapid and within the first 3-6 hours up to about 50% of each dose is cleared by urinary excretion.

Skeletal uptake of the complex occurs as a function of blood flow to bone and bone efficiency in extracting the complex. Bone mineral crystals are generally considered to be hydroxyapatite, and the complex appears to have an affinity for the hydroxyapatite crystals in bone.

Last reviewed on RxList: 10/3/2007
This monograph has been modified to include the generic and brand name in many instances.

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