Mebaral (Mephobarbital) Patient Information: Missed a Dose and What Should I Avoid at RxList

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May 27, 2012

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Sleep disorder drugs (hypnotic and sedative drugs) overview

Insomnia, a disorder of sleep, occurs occasionally in most people but usually lasts only a few days. The body then "corrects" itself naturally, and people return to a normal pattern of sleep. Insomnia may be short-term (less than three weeks) or chronic, lasting longer than three weeks. Contributing factors include, but are not limited to, poor sleeping habits, stress, jet lag, medications, disease, and depression. Chronic insomnia may warrant the use of sedative/hypnotics medications; however, it is important that the treating physician perform a complete diagnostic evaluation as well as take medication and substance abuse histories, to exclude secondary insomnia due to other conditions.

Hypnotics/sedatives medications (henceforth referred to as hypnotics) work, in general, by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain. Neuro...

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Mebaral Patient Information including If I Miss a Dose

What happens if I miss a dose (Mebaral)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Mebaral)?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of mephobarbital can be fatal.

Overdose symptoms may include slow or shallow breathing, blurred vision, extreme drowsiness, decreased body temperature, fast heart rate, and fainting.

What should I avoid while taking mephobarbital (Mebaral)?

Mephobarbital can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by mephobarbital. Tell your doctor if you need to use any of these other medicines while you are taking mephobarbital.

Do not drink alcohol while taking mephobarbital. Alcohol can increase the risk of fatal overdose with a barbiturate.

What other drugs will affect mephobarbital (Mebaral)?

Before taking mephobarbital, tell your doctor if you are also taking phenobarbital (Solfoton).

The following drugs can interact with mephobarbital. Tell your doctor if you are using any of these:

a blood thinner such as warfarin (Coumadin);
doxycycline (Adoxa, Doryx, Oracea, Vibramycin);
griseofulvin (Grisactin, Fulvicin PG, Grifulvin V);
steroid medicines such as hydrocortisone (Cortef, Hydrocortone), prednisone (Orasone, Deltasone), and others;
phenytoin (Dilantin), divalproex sodium (Depakote), valproic acid (Depakene); or
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).

This list is not complete and there may be other drugs that can interact with mephobarbital. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can more information about mephobarbital.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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