July 29, 2016
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"The U.S. Food and Drug Administration today approved Aptiom (eslicarbazepine acetate) as an add-on medication to treat seizures associated with epilepsy.

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Mebaral Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking mephobarbital (Mebaral)?

Do not take this medication if you are allergic to mephobarbital or to other barbiturates such as amobarbital (Amytal), butabarbital (Butisol), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use mephobarbital:

  • liver or kidney disease;
  • anemia (lack of red blood cells);
  • heart disease;
  • asthma, chronic obstructive pulmonary disorder (COPD), or other breathing disorder;
  • a history of depression, mental illness, or suicide attempt; or
  • a history of drug or alcohol addiction.

Mephobarbital may be habit-forming and should be used only by the person it was prescribed for. Mephobarbital should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

FDA pregnancy category D. This medication can cause harm to an unborn baby. It could also cause addiction or withdrawal symptoms in a newborn if the mother takes mephobarbital during late pregnancy. Do not use mephobarbital without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.

Mephobarbital can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking mephobarbital.

Mephobarbital can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take mephobarbital (Mebaral)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication. Mephobarbital is sometimes taken several times a day. Follow your doctor's instructions.

Take this medication with a full glass of water.

Do not stop using mephobarbital without first talking to your doctor, even if you feel better. You may have increased seizures if you stop using mephobarbital suddenly. You will need to use less and less before you stop the medication completely.

If you use this medication long-term, your blood may need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.

Store mephobarbital at room temperature away from moisture and heat.

Keep track of how many pills have been used from each new bottle of this medicine. Mephobarbital is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Side Effects Centers

Mebaral - User Reviews

Mebaral User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Mebaral sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Find tips and treatments to control seizures.