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Mefoxin

Last reviewed on RxList: 3/24/2017
Mefoxin Side Effects Center

Last reviewed on RxList 03/24/2017

Mefoxin (cefoxitin) is a cephalosporin antibiotic used to treat many kinds of bacterial infections, including severe or life-threatening forms. The brand name Mefoxin is discontinued in the U.S. Generic forms may be available. Common side effects of Mefoxin (cefoxitin) include:

Tell your doctor right away if you have any serious side effects of Mefoxin (cefoxitin) including:

  • dark urine,
  • easy bruising or bleeding,
  • fast/pounding/irregular heartbeat,
  • seizures,
  • unusual weakness,
  • yellowing eyes or skin, or
  • mental/mood changes (such as confusion).

The usual adult dosage range of cefoxitin is 1 gram to 2 grams every six to eight hours. Cefoxitin may interact with antibiotics. Other drugs may interact with cefoxitin. Tell your doctor all prescription and over-the-counter medications and supplements you use. Tell your doctor if you are pregnant before using cefoxitin. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Our Mefoxin (cefoxitin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Mefoxin Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • swelling, pain, or irritation where the injection was given;
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
  • feeling light-headed, fainting;
  • easy bruising or bleeding, unusual weakness;
  • fever, chills, body aches, flu symptoms;
  • urinating less than usual or not at all;
  • seizure (black-out or convulsions); or
  • jaundice (yellowing of the eyes or skin).

Less serious side effects are more likely to occur, such as:

  • nausea, vomiting, stomach pain;
  • mild skin rash; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Mefoxin (Cefoxitin)

Mefoxin Professional Information

SIDE EFFECTS

MEFOXIN is generally well tolerated. The most common adverse reactions have been local reactions following intravenous injection. Other adverse reactions have been encountered infrequently.

Local Reactions

Thrombophlebitis has occurred with intravenous administration.

Allergic Reactions

Rash (including exfoliative dermatitis and toxic epidermal necrolysis), urticaria, flushing, pruritus, eosinophilia, fever, dyspnea, and other allergic reactions including anaphylaxis, interstitial nephritis and angioedema have been noted.

Cardiovascular

Hypotension.

Gastrointestinal

Diarrhea, including documented pseudomembranous colitis which can appear during or after antibiotic treatment. Nausea and vomiting have been reported rarely.

Neuromuscular

Possible exacerbation of myasthenia gravis.

Blood

Eosinophilia, leukopenia including granulocytopenia, neutropenia, anemia, including hemolytic anemia, thrombocytopenia, and bone marrow depression. A positive direct Coombs test may develop in some individuals, especially those with azotemia.

Liver Function

Transient elevations in SGOT, SGPT, serum LDH, and serum alkaline phosphatase; and jaundice have been reported.

Renal Function

Elevations in serum creatinine and/or blood urea nitrogen levels have been observed. As with the cephalosporins, acute renal failure has been reported rarely. The role of MEFOXIN in changes in renal function tests is difficult to assess, since factors predisposing to prerenal azotemia or to impaired renal function usually have been present.

In addition to the adverse reactions listed above which have been observed in patients treated with MEFOXIN, the following adverse reactions and altered laboratory test results have been reported for cephalosporin class antibiotics: Urticaria, erythema multiforme, Stevens-Johnson syndrome, serum sickness-like reactions, abdominal pain, colitis, renal dysfunction, toxic nephropathy, false-positive test for urinary glucose, hepatic dysfunction including cholestasis, elevated bilirubin, aplastic anemia, hemorrhage, prolonged prothrombin time, pancytopenia, agranulocytosis, superinfection, vaginitis including vaginal candidiasis.

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced. (See DOSAGE AND ADMINISTRATION.) If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

Read the entire FDA prescribing information for Mefoxin (Cefoxitin)

Related Resources for Mefoxin

© Mefoxin Patient Information is supplied by Cerner Multum, Inc. and Mefoxin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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