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Megestrol acetate is a synthetic, antineoplastic and progestational drug. Megestrol acetate is a white, crystalline solid chemically designated as 17(alpha)-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione. Solubility at 37°C ater is 2 mcg per mL, solubility in plasma is 24 mcgin per w mL. Its molecular weight is 384.51. The molecular formula is C₂₄H₃₂O₄ and the structural formula is represented as follows:

Megestrol acetate is supplied as tablets for oral administration containing 20 mg and 40 mg megestrol acetate.

Megestrol acetate tablets contain the following inactive ingredients: acacia spray dried, colloidal silicon dioxide, corn starch, di-calcium phosphate dihydrate powder, lactose hydrous impalpable, magnesium stearate and pregelatinized starch.

Last reviewed on RxList: 6/3/2008
This monograph has been modified to include the generic and brand name in many instances.