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Menactra

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Menactra

Menactra®
Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine
FOR INTRAMUSCULAR INJECTION

Menactra

DRUG DESCRIPTION

Menactra®, Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, is a sterile, intramuscularly administered vaccine that contains Neisseria meningitidis serogroup A, C, Y and W-135 capsular polysaccharide antigens individually conjugated to diphtheria toxoid protein. N meningitidis A, C, Y and W-135 strains are cultured on Mueller Hinton agar1 and grown in Watson Scherp2 media. The polysaccharides are extracted from the N meningitidis cells and purified by centrifugation, detergent precipitation, alcohol precipitation, solvent extraction and diafiltration. To prepare the polysaccharides for conjugation, they are depolymerized, derivatized, and purified by diafiltration. Corynebacterium diphtheriae cultures are grown in a modified Mueller and Miller medium3 and detoxified with formaldehyde. The diphtheria toxoid protein is purified by ammonium sulfate fractionation and diafiltration. The derivatized polysaccharides are covalently linked to diphtheria toxoid and purified by serial diafiltration. The four meningococcal components, present as individual serogroup- specific glycoconjugates, compose the final formulated vaccine. No preservative or adjuvant is added during manufacture. Potency of Menactra (polysaccharide diphtheria toxoid conjugate vaccine) vaccine is determined by quantifying the amount of each polysaccharide antigen that is conjugated to diphtheria toxoid protein and the amount of unconjugated polysaccharide present.

Menactra (polysaccharide diphtheria toxoid conjugate vaccine) vaccine is manufactured as a sterile, clear to slightly turbid liquid. Each 0.5 mL dose of vaccine is formulated in sodium phosphate buffered isotonic sodium chloride solution to contain 4 g each of meningococcal A, C, Y, and W-135 polysaccharides conjugated to approximately 48 g of diphtheria toxoid protein carrier.

What are the possible side effects of meningococcal conjugate vaccine (Menactra, Menveo)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects. Your child should not receive a booster vaccine if he or she had a life threatening allergic reaction after the first shot.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

You may feel faint after receiving this vaccine. Some people...

Read All Potential Side Effects and See Pictures of Menactra »

What are the precautions when taking polysaccharide diphtheria toxoid conjugate vaccine (Menactra)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with...

Read All Potential Precautions of Menactra »

REFERENCES

What are the possible side effects of meningococcal conjugate vaccine (Menactra, Menveo)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects. Your child should not receive a booster vaccine if he or she had a life threatening allergic reaction after the first shot.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

You may feel faint after receiving this vaccine. Some people...

Read All Potential Side Effects and See Pictures of Menactra »

What are the precautions when taking polysaccharide diphtheria toxoid conjugate vaccine (Menactra)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with...

Read All Potential Precautions of Menactra »

1. Mueller JH, et al. A Protein-Free Medium for Primary Isolation of the Gonococcus and Meningococcus. Proc Soc Exp Biol Med 1941;48:330-333.

What are the possible side effects of meningococcal conjugate vaccine (Menactra, Menveo)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects. Your child should not receive a booster vaccine if he or she had a life threatening allergic reaction after the first shot.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

You may feel faint after receiving this vaccine. Some people...

Read All Potential Side Effects and See Pictures of Menactra »

What are the precautions when taking polysaccharide diphtheria toxoid conjugate vaccine (Menactra)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with...

Read All Potential Precautions of Menactra »

2. Watson RG, et al. The specific hapten of group C (group IIα) meningococcus. I. Preparation and immunological behavior. J Immunol 1958;81:331-336.

What are the possible side effects of meningococcal conjugate vaccine (Menactra, Menveo)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects. Your child should not receive a booster vaccine if he or she had a life threatening allergic reaction after the first shot.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

You may feel faint after receiving this vaccine. Some people...

Read All Potential Side Effects and See Pictures of Menactra »

What are the precautions when taking polysaccharide diphtheria toxoid conjugate vaccine (Menactra)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with...

Read All Potential Precautions of Menactra »

3. Mueller JH, et al. Production of diphtheria toxin of high potency (100 Lf) on a reproducible medium. J Immunol 1941;40:21- 32.

What are the possible side effects of meningococcal conjugate vaccine (Menactra, Menveo)?

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects. Your child should not receive a booster vaccine if he or she had a life threatening allergic reaction after the first shot.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

You may feel faint after receiving this vaccine. Some people...

Read All Potential Side Effects and See Pictures of Menactra »

What are the precautions when taking polysaccharide diphtheria toxoid conjugate vaccine (Menactra)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, a certain nerve disease (Guillain-Barre syndrome), bleeding disorders (such as hemophilia, thrombocytopenia).

This vaccine can cause some patients to faint, which could cause falling and injury. To reduce the risk of this side effect, your doctor may recommend that you stay in a sitting or lying position for 15 minutes after the injection. Infrequently, fainting along with...

Read All Potential Precautions of Menactra »

Last reviewed on RxList: 10/30/2007
This monograph has been modified to include the generic and brand name in many instances.

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