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Menomune

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Menomune

Menomune® - A/C/Y/W-135
Meningococcal Polysaccharide Vaccine, Groups A, C, Y and W-135 Combined

DRUG DESCRIPTION

Menomune®- A/C/Y/W-135, Meningococcal Polysaccharide Vaccine, Groups A, C, Y and W-135 Combined, for subcutaneous use, is a freeze-dried preparation of the group-specific polysaccharide antigens from Neisseria meningitidis, Group A, Group C, Group Y and Group W-135. N meningitidis are cultivated with Mueller Hinton agar1 and Watson Scherp2 media. The purified polysaccharide is extracted from the Neisseria meningitidis cells and separated from the media by procedures which include centrifugation, detergent precipitation, alcohol precipitation, solvent or organic extraction and diafiltration. No preservative is added during manufacture.

The 0.78 mL vial of diluent contains sterile, preservative-free, pyrogen-free distilled water and is used for reconstitution of product supplied in 1 mL vials. The 6 mL vial of diluent contains sterile, pyrogen-free distilled water to which thimerosal (mercury derivative) 1:10,000 is added as a preservative. The 6 mL vial is for reconstitution of product supplied in 10 mL vials. After reconstitution with diluent as indicated on the label, the 0.5 mL dose is formulated to contain 50 µg of “isolated product” from each of Groups A, C, Y and W-135 in an isotonic sodium chloride solution.

Each dose of vaccine is also formulated to contain 2.5 mg to 5 mg of lactose added as a stabilizer.3 The vaccine when reconstituted is a clear colorless liquid.

Potency is evaluated by measuring the molecular size of each polysaccharide component using a column chromatography method as standardized by the US Food and Drug Administration (FDA) and the World Health Organization (WHO)4 for Meningococcal Polysaccharide Vaccine.

THIS VACCINE CONFORMS TO THE WORLD HEALTH ORGANIZATION (WHO) REQUIREMENTS.

What are the possible side effects of this vaccine (Menomune A/C/Y/W-135)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever need to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Developing meningitis (infection of the spinal cord and lining of the brain) is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic...

Read All Potential Side Effects and See Pictures of Menomune »

What are the precautions when taking meningococcal polysaccharide vaccine (Menomune)?

See also How to Use and Drug Interactions sections.

Before receiving this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as latex or dry natural rubber that can be found in the vial stopper), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: your vaccination/immunization history, recent illness or fever, immune system problems (e.g., due to cancer treatment, organ transplant, HIV).

Some brands of this product may contain a small amount of mercury from a preservative (thimerosal). Consult your doctor for more...

Read All Potential Precautions of Menomune »

REFERENCES

What are the possible side effects of this vaccine (Menomune A/C/Y/W-135)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever need to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Developing meningitis (infection of the spinal cord and lining of the brain) is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic...

Read All Potential Side Effects and See Pictures of Menomune »

What are the precautions when taking meningococcal polysaccharide vaccine (Menomune)?

See also How to Use and Drug Interactions sections.

Before receiving this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as latex or dry natural rubber that can be found in the vial stopper), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: your vaccination/immunization history, recent illness or fever, immune system problems (e.g., due to cancer treatment, organ transplant, HIV).

Some brands of this product may contain a small amount of mercury from a preservative (thimerosal). Consult your doctor for more...

Read All Potential Precautions of Menomune »

1. Mueller H, et al. A protein-free medium for primary isolation of the gonococcus and meningococcus. Proc Soc Exp Biol Med 48: 330, 1941

What are the possible side effects of this vaccine (Menomune A/C/Y/W-135)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever need to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Developing meningitis (infection of the spinal cord and lining of the brain) is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic...

Read All Potential Side Effects and See Pictures of Menomune »

What are the precautions when taking meningococcal polysaccharide vaccine (Menomune)?

See also How to Use and Drug Interactions sections.

Before receiving this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as latex or dry natural rubber that can be found in the vial stopper), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: your vaccination/immunization history, recent illness or fever, immune system problems (e.g., due to cancer treatment, organ transplant, HIV).

Some brands of this product may contain a small amount of mercury from a preservative (thimerosal). Consult your doctor for more...

Read All Potential Precautions of Menomune »

2. Watson RG, et al. The specific hapten ofgroup C (group II a) meningococcus. II. Chemical nature. J Immunol. 81: 337, 1958

What are the possible side effects of this vaccine (Menomune A/C/Y/W-135)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever need to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Developing meningitis (infection of the spinal cord and lining of the brain) is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic...

Read All Potential Side Effects and See Pictures of Menomune »

What are the precautions when taking meningococcal polysaccharide vaccine (Menomune)?

See also How to Use and Drug Interactions sections.

Before receiving this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as latex or dry natural rubber that can be found in the vial stopper), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: your vaccination/immunization history, recent illness or fever, immune system problems (e.g., due to cancer treatment, organ transplant, HIV).

Some brands of this product may contain a small amount of mercury from a preservative (thimerosal). Consult your doctor for more...

Read All Potential Precautions of Menomune »

3. Tiesjema RH, et al. Enhanced stability of meningococcal polysaccharide vaccines by using lactose as a menstruum for lyophilization. Bull WHO 55: 43-48, 1977

What are the possible side effects of this vaccine (Menomune A/C/Y/W-135)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever need to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Developing meningitis (infection of the spinal cord and lining of the brain) is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic...

Read All Potential Side Effects and See Pictures of Menomune »

What are the precautions when taking meningococcal polysaccharide vaccine (Menomune)?

See also How to Use and Drug Interactions sections.

Before receiving this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as latex or dry natural rubber that can be found in the vial stopper), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: your vaccination/immunization history, recent illness or fever, immune system problems (e.g., due to cancer treatment, organ transplant, HIV).

Some brands of this product may contain a small amount of mercury from a preservative (thimerosal). Consult your doctor for more...

Read All Potential Precautions of Menomune »

4. WHO Technical Report Series, No. 658, 1981

What are the possible side effects of this vaccine (Menomune A/C/Y/W-135)?

Keep track of any and all side effects you have after receiving this vaccine. If you ever need to receive another meningococcal vaccine in the future, you will need to tell the doctor if the first shot caused any side effects.

Developing meningitis (infection of the spinal cord and lining of the brain) is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic...

Read All Potential Side Effects and See Pictures of Menomune »

What are the precautions when taking meningococcal polysaccharide vaccine (Menomune)?

See also How to Use and Drug Interactions sections.

Before receiving this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as latex or dry natural rubber that can be found in the vial stopper), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: your vaccination/immunization history, recent illness or fever, immune system problems (e.g., due to cancer treatment, organ transplant, HIV).

Some brands of this product may contain a small amount of mercury from a preservative (thimerosal). Consult your doctor for more...

Read All Potential Precautions of Menomune »

Last reviewed on RxList: 9/18/2008
This monograph has been modified to include the generic and brand name in many instances.

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