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Menostar Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Menostar (estradiol) Transdermal System is a form of estrogen, a female sex hormone, used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area. It also reduces urgency or irritation of urination. Menostar skin patches are also used to treat ovarian disorders, infertility, and abnormal vaginal bleeding. Some estradiol skin patches are used to prevent postmenopausal osteoporosis. Common side effects include nausea, vomiting, loss of appetite, swollen breasts, acne, skin color changes, decreased sex drive, impotence, difficulty having an orgasm, migraine headaches, dizziness, vaginal pain, dryness, or discomfort, swelling of your ankles or feet, depression, changes in your menstrual periods, or break-through bleeding.
The adhesive side of the Menostar transdermal system should be placed on a clean, dry area of the lower abdomen. Menostar should not be applied to or near the breasts. The sites of application must be rotated, with an interval of at least 1-week allowed between applications to a particular site. Menostar may interact with carbamazepine, phenobarbital, St. John's wort, blood thinners, antibiotics, antifungals, or ritonavir and other HIV/AIDS medications. Tell your doctor all medications and supplements you use. Do not use Menostar if you are pregnant. It can cause birth defects. Tell your doctor right away if you become pregnant during treatment. Use birth control while you are using this medication. This drug can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use Menostar while breastfeeding.
Our Menostar (estradiol) Transdermal System Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Menostar in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
- sudden numbness or weakness, especially on one side of the body;
- sudden severe headache, sudden vision changes, problems with speech or balance;
- sudden cough, wheezing, rapid breathing, coughing up blood;
- pain, swelling, warmth, or redness in one or both legs;
- pain, swelling, or tenderness in your stomach;
- jaundice (yellowing of the skin or eyes);
- unusual vaginal bleeding;
- a lump in your breast;
- numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes; or
- dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Less serious side effects may include:
- upset stomach, bloating, constipation;
- acne or skin color changes, increased facial hair, thinning scalp hair;
- mild headache, back pain, joint pain;
- cold symptoms such as stuffy nose, sneezing, sinus pain, sore throat;
- breast swelling and tenderness, nipple discharge; or
- changes in your menstrual periods, break-through bleeding.
Read the entire detailed patient monograph for Menostar (Estradiol Transdermal System) »
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Menostar FDA Prescribing Information: Side Effects
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The adverse reaction information from clinical trials does, however, provide a basis for identifying the adverse events that appear to be related to drug use and for approximating rates.
Summary of Most Frequently Reported Treatment Emergent Adverse
Experiences/Medical Events ( ≥ 5%) By Treatment Groups
|AE per Body System||Menostar 14 mcg/day
|Body as a Whole||95 (46%)||100 (48%)|
|Abdominal Pain||17 (8%)||17 (8%)|
|Accidental Injury||29 (14%)||23 (11%)|
|Infection||11 (5%)||10 (5%)|
|Pain||26 (13%)||26 (12%)|
|Cardiovascular||20 (10%)||19 (9%)|
|Digestive System||52 (25%)||44 (21%)|
|Constipation||11 (5%)||6 (3%)|
|Dyspepsia||11 (5%)||9 (4%)|
|Metabolic and Nutritional Disorders||25 (12%)||22 (11%)|
|Musculoskeletal System||54 (26%)||51 (24%)|
|Arthralgia||24 (12%)||13 (6%)|
|Arthritis||11 (5%)||15 (7%)|
|Myalgia||10 (5%)||6 (3%)|
|Nervous System||30 (14%)||23 (11%)|
|Dizziness||11 (5%)||6 (3%)|
|Repiratory System||62 (30%)||67 (32%)|
|Bronchitis||12 (6%)||9 (4%)|
|Upper Respiratory Infection||33 (16%)||35 (17%)|
|Skin and Appendages||50 (24%)||54 (26%)|
|Application Site Reaction||18 (9%)||18 (9%)|
|Breast Pain||10 (5%)||8 (4%)|
|Urogenital System||66 (32%)||40 (19%)|
|Cervical Polyps||13 (6%)||4 (2%)|
|Leukorrhea||22 (11%)||3 (1%)|
The following additional adverse reactions have been reported with estrogens and/or progestin therapy.
Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding; spotting; dysmenorrhea; increase in size of uterine leiomyomata; vaginitis, including vaginal candidiasis; change in amount of cervical secretion; changes in cervical ectropion; ovarian cancer; endometrial hyperplasia; endometrial cancer.
Retinal vascular thrombosis; intolerance to contact lenses.
Central nervous system
Increase or decrease in weight; reduced carbohydrate tolerance; aggravation of porphyria; edema; arthalgias; leg cramps; changes in libido; anaphylactoid/ana-phylactic reactions including urticaria and angioedema; hypocalcemia; exacerbation of asthma; increased triglycerides.
Read the entire FDA prescribing information for Menostar (Estradiol Transdermal System) »
Additional Menostar Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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