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Meridia

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Meridia

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Indications
Dosage
How Supplied

INDICATIONS

MERIDIA (sibutramine hydrochloride monohydrate) is indicated for the management of obesity, including weight loss and maintenance of weight loss, and should be used in conjunction with a reduced calorie diet. MERIDIA (sibutramine hydrochloride monohydrate) is recommended for obese patients with an initial body mass index ≥ 30 kg/m², or ≥ 27 kg/m² in the presence of other risk factors (e.g., diabetes, dyslipidemia, controlled hypertension).

Below is a chart of Body Mass Index (BMI) based on various heights and weights.

BMI is calculated by taking the patient's weight, in kg, and dividing by the patient's height, in meters, squared. Metric conversions are as follows: pounds 2.2 = kg; inches 0.0254 = meters.

BMI   25 26 27 28 29 30 31 32 33 34 35 40
  W E I G H T (lbs)
4'10" 119 124 129 134 138 143 149 153 158 163 167 191
4'11" 124 128 133 138 143 148 154 158 164 169 173 198
5' 128 133 138 143 148 153 159 164 169 175 179 204
5'1" 132 137 143 148 153 158 165 169 175 180 185 211
5'2" 136 142 147 153 158 164 170 175 181 186 191 218
H 5'3" 141 146 152 158 163 169 175 181 187 192 197 225
5'4" 145 151 157 163 169 174 181 187 193 199 204 232
E 5'5" 150 156 162 168 174 180 187 193 199 205 210 240
5'6" 155 161 167 173 179 186 192 199 205 211 216 247
I 5'7" 159 166 172 178 185 191 198 205 211 218 223 255
5'8" 164 171 177 184 190 197 204 211 218 224 230 262
G 5'9" 169 176 182 189 196 203 210 217 224 231 236 270
5'10" 174 181 188 195 202 207 216 223 230 237 243 278
H 5'11" 179 186 193 200 208 215 222 230 237 244 250 286
6' 184 191 199 206 213 221 228 236 244 251 258 294
T 6'1" 189 197 204 212 219 227 236 243 251 258 265 302
6'2" 194 202 210 218 225 233 241 250 258 265 272 311
6'3" 200 208 216 224 232 240 248 256 264 272 279 319

DOSAGE AND ADMINISTRATION

The recommended starting dose of MERIDIA (sibutramine hydrochloride monohydrate) is 10 mg administered once daily with or without food. If there is inadequate weight loss, the dose may be titrated after four weeks to a total of 15 mg once daily. The 5 mg dose should be reserved for patients who do not tolerate the 10 mg dose. Blood pressure and heart rate changes should be taken into account when making decisions regarding dose titration (see WARNINGS and PRECAUTIONS).

Doses above 15 mg daily are not recommended. In most of the clinical trials, MERIDIA (sibutramine hydrochloride monohydrate) was given in the morning.

Analysis of numerous variable s has indicated that approximately 60% of patients who lose at least 4 pounds in the first 4 weeks of treatment with a given dose of MERIDIA (sibutramine hydrochloride monohydrate) in combination with a reduced-calorie diet lose at least 5% (placebo-subtracted) of their initial body weight by the end of 6 months to 1 year of treatment on that dose of MERIDIA (sibutramine hydrochloride monohydrate) . Conversely , approximately 80% of patients who do not lose at least 4 pounds in the first 4 weeks of treatment with a given dose of MERIDIA (sibutramine hydrochloride monohydrate) do not lose at least 5% (placebo-subtracted) of their initial body weight by the end of 6 months to 1 year of treatment on that dose. If a patient has not lost at least 4 pounds in the first 4 weeks of treatment, the physician should consider reevaluation of therapy which may include increasing the dose or discontinuation of MERIDIA (sibutramine hydrochloride monohydrate) .

The safety and effectiveness of MERIDIA (sibutramine hydrochloride monohydrate) , as demonstrated in double-blind, placebo-controlled trials, have not been determined beyond 2 years at this time.

HOW SUPPLIED

MERIDIA® (sibutramine hydrochloride monohydrate) Capsules contain 5 mg, 10 mg, or 15 mg sibutramine hydrochloride monohydrate and are supplied as follows:

5 mg, NDC 0074-2456-12, blue/yellow capsules imprinted with “MERIDIA (sibutramine hydrochloride monohydrate) ” on the cap and ”-5-“ on the body, in bottles of 30 capsules.

10 mg, NDC 0074-2457-12, blue/white capsules imprinted with ”MERIDIA (sibutramine hydrochloride monohydrate) ” on the cap and “-10-” on the body, in bottles of 30 capsules.

15 mg, NDC 0074-2458-12, yellow/white capsules imprinted with “MERIDIA (sibutramine hydrochloride monohydrate) ” on the cap and “-15-” on the body, in bottles of 30 capsules.

Storage

Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F) [see USP controlled room temperature]. Protect capsules from heat and moisture. Dispense in a tight, light-resistant container as defined in USP.

Manufactured for Abbott Laboratories, North Chicago, IL 60064 USA by KNOLL LLC B.V. Jayuya, PR, 00664.

Last reviewed on RxList: 1/31/2011
This monograph has been modified to include the generic and brand name in many instances.

Indications
Dosage
How Supplied
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Meridia - User Reviews

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