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Meruvax

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Meruvax

MERUVAX® II
(rubella virus) Vaccine Live

Wistar RA 27/3 Strain

Meruvax

DRUG DESCRIPTION

MERUVAX® II (Rubella Virus Vaccine Live) is a live virus vaccine for vaccination against rubella (German measles).

MERUVAX (rubella virus vaccine live) II is a sterile lyophilized preparation of the Wistar Institute RA 27/3 strain of live attenuated rubella virus. The virus was adapted to and propagated in WI-38 human diploid lung fibroblasts.1,2

The growth medium is Minimum Essential Medium (MEM) [a buffered salt solution containing vitamins and amino acids and supplemented with fetal bovine serum] containing human serum albumin and neomycin. Sorbitol and hydrolyzed gelatin stabilizer are added to the individual virus harvests.

The cells, virus pools, fetal bovine serum, and human albumin are all screened for the absence of adventitious agents. Human albumin is processed using the Cohn cold ethanol fractionation procedure.

The reconstituted vaccine is for subcutaneous administration. Each 0.5 mL dose contains not less than 1,000 TCID50 (tissue culture infectious doses) of rubella virus. Each dose of the vaccine is calculated to contain sorbitol (14.5 mg), sodium phosphate, sucrose (1.9 mg), sodium chloride, hydrolyzed gelatin (14.5 mg), human albumin (0.3 mg), fetal bovine serum ( < 1 ppm), other buffer and media ingredients and approximately 25 mcg of neomycin. The product contains no preservative.

Before reconstitution, the lyophilized vaccine is a light yellow compact crystalline plug. MERUVAX (rubella virus vaccine live) II, when reconstituted as directed, is clear yellow.

What are the possible side effects of rubella virus vaccines (Meruvax II)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get...

Read All Potential Side Effects and See Pictures of Meruvax »

What are the precautions when taking rubella virus vaccine live (Meruvax)?

Before receiving rubella virus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, gelatin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: illness with a high fever over 101 degrees F (38 degrees C), decreased immune function from other medications (see also Drug Interactions), decreased immune function from other illness (e.g., advanced HIV/AIDS, leukemia, lymphoma, other cancer affecting the bone marrow or lymph nodes), immune problems with certain white blood cells...

Read All Potential Precautions of Meruvax »

REFERENCES

What are the possible side effects of rubella virus vaccines (Meruvax II)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get...

Read All Potential Side Effects and See Pictures of Meruvax »

What are the precautions when taking rubella virus vaccine live (Meruvax)?

Before receiving rubella virus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, gelatin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: illness with a high fever over 101 degrees F (38 degrees C), decreased immune function from other medications (see also Drug Interactions), decreased immune function from other illness (e.g., advanced HIV/AIDS, leukemia, lymphoma, other cancer affecting the bone marrow or lymph nodes), immune problems with certain white blood cells...

Read All Potential Precautions of Meruvax »

1. Plotkin, S.A.; Cornfeld, D.; Ingalls, T.H.: Studies of immunization with living rubella virus: Trials in children with a strain cultured from an aborted fetus, Am. J. Dis. Child. 110: 381-389, 1965.

What are the possible side effects of rubella virus vaccines (Meruvax II)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get...

Read All Potential Side Effects and See Pictures of Meruvax »

What are the precautions when taking rubella virus vaccine live (Meruvax)?

Before receiving rubella virus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, gelatin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: illness with a high fever over 101 degrees F (38 degrees C), decreased immune function from other medications (see also Drug Interactions), decreased immune function from other illness (e.g., advanced HIV/AIDS, leukemia, lymphoma, other cancer affecting the bone marrow or lymph nodes), immune problems with certain white blood cells...

Read All Potential Precautions of Meruvax »

2. Plotkin, S.A.; Farquhar, J.; Katz, M.; Ingalls, T.H.: A new attenuated rubella virus grown in human fibroblasts: Evidence for reduced nasopharyngeal excretion, Am. J. Epidemiol. 86: 468-477, 1967.

What are the possible side effects of rubella virus vaccines (Meruvax II)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with measles, mumps, or rubella is much more dangerous to your health than receiving the vaccine to protect against these diseases. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get...

Read All Potential Side Effects and See Pictures of Meruvax »

What are the precautions when taking rubella virus vaccine live (Meruvax)?

Before receiving rubella virus vaccine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as neomycin, gelatin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: illness with a high fever over 101 degrees F (38 degrees C), decreased immune function from other medications (see also Drug Interactions), decreased immune function from other illness (e.g., advanced HIV/AIDS, leukemia, lymphoma, other cancer affecting the bone marrow or lymph nodes), immune problems with certain white blood cells...

Read All Potential Precautions of Meruvax »

Last reviewed on RxList: 10/20/2008
This monograph has been modified to include the generic and brand name in many instances.

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