April 27, 2017
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(mesna) Tablets and Injection

What is the most important information I should know about MESNEX?

MESNEX can cause serious allergic reactions and skin reactions. These side effects can happen the first time you are treated with MESNEX, or after several months of treatment with MESNEX. Stop treatment with MESNEX and call your doctor or go to the nearest hospital emergency room right away if you develop any of the symptoms listed below:

  • fever
  • swelling of your face, lips, mouth, or tongue
  • trouble breathing or wheezing
  • itching
  • burning
  • skin rash or hives
  • skin redness or swelling
  • skin blisters or peeling
  • feel lightheaded or faint
  • feel like your heart is racing
  • nausea or vomiting
  • joint or muscle aches
  • mouth sores

See “What are the possible side effects of MESNEX?” for more information about side effects.

What is MESNEX?

MESNEX is a prescription medicine used to reduce the risk of inflammation and bleeding of the bladder (hemorrhagic cystitis) in people who receive ifosfamide (a medicine used to treat cancer).

MESNEX is not for use to reduce the risk of blood in the urine (hematuria) due to other medical conditions.

It is not known if MESNEX is safe and effective in children.

Who should not receive MESNEX?

Do not take MESNEX if you are allergic to MESNEX or any of the ingredients in MESNEX. See the end of this leaflet for a complete list of ingredients in MESNEX.

What should I tell my doctor before receiving MESNEX?

Before you receive MESNEX, tell your doctor if you:

  • have any other medical conditions
  • are pregnant or plan to become pregnant. It is not known if MESNEX will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if MESNEX passes into your breast milk. You and your doctor should decide if you will receive MESNEX or breastfeed. You should not do both.

Tell your doctor about all the medicines you take, including prescription and over-thecounter medicines, vitamins, and herbal supplements.

How will I receive MESNEX?

  • MESNEX is given on the same day that you receive ifosfamide.
  • MESNEX can be given by an intravenous (IV) infusion into a vein or tablets taken by mouth.
  • You will receive MESNEX in one of two ways:
  1. MESNEX intravenous (IV) infusion into a vein at the time you receive ifosfamide and 4 and 8 hours after you receive ifosfamide.
  2. MESNEX intravenous (IV) infusion into a vein at the time you receive ifosfamide and MESNEX tablets taken by mouth 2 and 6 hours after you receive ifosfamide.
  • Take MESNEX tablets at the exact times and the exact dose your doctor tells you to take it.
  • You may need to take half of a MESNEX tablet for your complete dose. Each tablet has a groove in the middle that will make it easier to break the tablet in half.
  • During treatment with MESNEX,you should drink 4 to 8 cups of liquid (1 to 2 liters) each day, whether you receive MESNEX by intravenous infusion or take MESNEX tablets by mouth.
  • Tell your doctor if you:
    • vomit within 2 hours of taking MESNEX tablets by mouth
    • miss a dose of MESNEX tablets
    • have pink or red colored urine

What are the possible side effects of MESNEX?

MESNEX may cause serious side effects, including:

See “What is the most important information I should know about MESNEX?”

  • MESNEX that is given by intravenous infusion contains the preservative benzyl alcohol. Benzyl alcohol has been shown to cause serious side effects and death in newborn, premature, and low-birth weight babies. MESNEX tablets do not contain benzyl alcohol.

The most common side effects of MESNEX when given with ifosfamide include:

  • nausea
  • vomiting
  • constipation
  • decreased white blood cell count
  • tiredness
  • fever
  • decreased appetite
  • decreased platelet count
  • decreased red blood cell count
  • diarrhea
  • weakness
  • stomach (abdomen) pain
  • headache
  • hair loss
  • sleepiness

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of MESNEX. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store MESNEX tablets?

  • Store MESNEX tablets at room temperature between 68°F to 77°F (20°C to 25°C).

Keep MESNEX and all medicines out of the reach of children.

General information about the safe and effective use of MESNEX

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use MESNEX for a condition for which it was not prescribed. Do not give MESNEX to other people, even if they have the same symptoms that you have. It may harm them. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about MESNEX that is written for health professionals.

For more information, call 1-800-262-3784.

What are the ingredients in MESNEX?

Active ingredient: mesna

Inactive ingredients:

MESNEX injection: edetate disodium, sodium hydroxide, and benzyl alcohol as a preservative.

MESNEX tablets: calcium phosphate, cornstarch, hydroxypropylmethylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, simethicone, and titanium dioxide.

This Patient Information has been approved by the U.S. Food and Drug Administration.

Last reviewed on RxList: 3/7/2017
This monograph has been modified to include the generic and brand name in many instances.

Mesnex - User Reviews

Mesnex User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Mesnex sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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