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Metaglip Patient Information Including Side Effects

Brand Names: Metaglip

Generic Name: glipizide and metformin (Pronunciation: GLIP ih zyd and met FOR min)

What is glipizide and metformin (Metaglip)?

Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

Glipizide and metformin is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes.

Glipizide and metformin may also be used for purposes not listed in this medication guide.

Glipizide-Metformin 2.5 mg-250 mg-MYL

round, white, imprinted with G31, M

Glipizide-Metformin 2.5 mg-250 mg-TEV

oblong, pink, imprinted with 93, 7455

Glipizide-Metformin 2.5 mg-500 mg-MYL

oblong, white, imprinted with M, G32

Glipizide-Metformin 2.5 mg-500 mg-TEV

oblong, white, imprinted with 93, 7456

Glipizide-Metformin 5 mg-500 mg-MYL

oblong, peach, imprinted with M, G33

Glipizide-Metformin 5 mg-500 mg-TEV

oblong, pink, imprinted with 93, 7457

Metaglip 2.5 mg-250 mg

oval, pink, imprinted with BMS, 6081

Metaglip 2.5-500 mg

oval, white, imprinted with BMS, 6077

Metaglip 5-500 mg

oval, pink, imprinted with BMS, 6078

What are the possible side effects of glipizide and metformin (Metaglip)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.

Stop taking this medication and call your doctor at once if you have a serious side effect such as:

  • feeling short of breath, even with mild exertion, swelling or rapid weight gain;
  • pain or burning with urination;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • headache, dizziness;
  • mild nausea, vomiting, diarrhea, stomach pain; or
  • joint or muscle pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Metaglip (glipizide and metformin) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about glipizide and metformin (Metaglip)?

Do not use glipizide and metformin if you have congestive heart failure or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glipizide and metformin.

Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Some people develop lactic acidosis while taking metformin. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.

Side Effects Centers

Metaglip - User Reviews

Metaglip User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Metaglip sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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