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Metastron

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Metastron

METASTRON™
(strontium-89 chloride) Injection

DRUG DESCRIPTION

Metastron is a sterile, non-pyrogenic, aqueous solution of Strontium-89 Chloride for intravenous administration. The solution contains no preservative.

Each milliliter contains:

Strontium Chloride 10.9 -22.6 mg
Water for Injection q.s. to 1 mL

The radioactive concentration is 37 MBq/mL, 1 mCi/mL, and the specific activity is 2.96-6.17 MBq/mg, 80-167 μCi/mg at calibration. The pH of the solution is 4 -7.5.

Physical Characteristics

Strontium-89 decays by beta emission with a physical half-life of 50.5 days. The maximum beta energy is 1.463 MeV (100%). The maximum range of β-from Strontium-89 in tissue is approximately 8 mm.

Radioactive decay factors to be applied to the stated value for radioactive concentration at calibration, when calculating injection volumes at the time of administration, are given in Table 1.

Table 1: Decay of Strontium-89

Day* Factor Day* Factor
-24 1.39 +6 0.92
-22 1.35 +8 0.90
-20 1.32 +10 0.87
-18 1.28 +12 0.85
-16 1.25 +14 0.83
-14 1.21 +16 0.80
-12 1.18 +18 0.78
-10 1.15 +20 0.76
-8 1.12 +22 0.74
-6 1.09 +24 0.72
-4 1.06 +26 0.70
-2 1.03 +28 0.68
0=calibration 1.00    
* Days before (-) or after (+) the calibration date stated on the vial.

Last reviewed on RxList: 1/24/2014
This monograph has been modified to include the generic and brand name in many instances.

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